L-365,260

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Cat.No. 2767 - L-365,260 | C24H22N4O2 | CAS No. 118101-09-0
Description: Selective CCK2 antagonist
Chemical Name: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.

Technical Data

M. Wt 398.46
Formula C24H22N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 118101-09-0
PubChem ID 5311201
InChI Key KDFQABSFVYLGPM-QFIPXVFZSA-N
Smiles O=C1[C@H](NC(NC4=CC=CC(C)=C4)=O)N=C(C3=CC=CC=C3)C2=C(C=CC=C2)N1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.85 100
ethanol 39.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 398.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kees et al (1989) Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. J.Med.Chem. 32 13 PMID: 2909725

Lotti and Chang (1989) A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. Eur.J.Pharmacol. 162 273 PMID: 2721567

Chung et al (2009) Cholecystokinin action on layer 6b neurons in somatosensory cortex. Brain Res. 1282 10 PMID: 19497313


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Keywords: L-365,260, supplier, Selective, CCK2, antagonists, Cholecystokinin2, Receptors, L365260, CCK2, Receptor, Tocris Bioscience

1 Citation for L-365,260

Citations are publications that use Tocris products. Selected citations for L-365,260 include:

Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417


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