CCK1 Receptors

The cholecystokinin1 receptor (CCK1 receptor, CCK-A receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK2. CCK1 receptors play a role in food intake, pancreatic exocrine secretion, gall bladder contractility and GI motility.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2411 A-71623
Potent and selective CCK1 agonist; suppresses feeding

Antagonists

Cat No Product Name / Activity
2304 Devazepide
Selective, orally active CCK1 receptor antagonist
2190 SR 27897
Potent and selective CCK1 antagonist

Related Targets

    The cholecystokinin1 receptor (CCK1 receptor, CCK-A receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK2. They are located primarily in the pancreas, gall bladder, intestine and vagus nerve where they play a role in food intake, pancreatic exocrine secretion, gall bladder contractility and GI motility. The human CCK1 receptor gene has been localized to chromosome 4 (4p15.1-p15.2).

    External sources of pharmacological information for CCK1 Receptors :

    Literature for CCK1 Receptors

    GPCR

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    Peptide Hormone Receptors

    Peptide Hormone Receptors Product Listing

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    Peptides Involved in Appetite Modulation

    Peptides Involved in Appetite Modulation Scientific Review

    Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

    CCK1 Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human CCKAR NM_000730 P32238
    Mouse Cckar NM_009827 O08786
    Rat Cckar NM_012688 P30551