Gastrin I (human)

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Cat.No. 3006 - Gastrin I (human) | Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 | CAS No. 10047-33-3
Description: Selective CCK2 agonist
Datasheet
Citations (6)
Reviews (1)
Literature (3)

Biological Activity

Endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Stimulates gastric acid secretion. Also used in the culture of stomach organoids.

Technical Data

M. Wt 2098.22
Formula C97H124N20O31S
Sequence XGPWLEEEEEAYGWMDF

(Modifications: X = Glp, Phe-17 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 10047-33-3
PubChem ID 16162108
InChI Key GKDWRERMBNGKCZ-RNXBIMIWSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 1% Ammonia with sonication

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Noble et al (1999) International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol.Rev. 51 745 PMID: 10581329

Blandizzi et al (1999) CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur.J.Pharmacol. 373 71 PMID: 10408253

Sato et al (2015) SnapShot: Growing Organoids from Stem Cells. Cell 161 1700 PMID: 26091044

Mahe et al (2014) Establishment of gastrointestinal epithelial organoids Curr.Protoc. Mouse Biol. 3 217 PMID: 25105065

Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 126 PMID: 25307862


If you know of a relevant reference for Gastrin I (human), please let us know.

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Keywords: Gastrin I (human), Gastrin I (human) supplier, Selective, CCK2, agonists, Cholecystokinin2, Receptors, GastrinI, (human), organoids, Receptor, Organoids, 3006, Tocris Bioscience

6 Citations for Gastrin I (human)

Citations are publications that use Tocris products. Selected citations for Gastrin I (human) include:

Post et al (2020) Snake venom gland organoids. Cell 180 233 PMID: 31978343

Colomer et al (2019) IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Mol Cell 75 669 PMID: 31302002

Filippini et al (2019) Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease. Sci Rep 9 12286 PMID: 31439856

Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology. 148 126 PMID: 25307862


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Reviews for Gastrin I (human)

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Stimulation of pancreatic acinar cells.
By Anonymous on 06/06/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Pancreatic acinar cells

Used to stimulate pancreatic acinar cells to secrete digestive enzymes in vitro


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