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Biological Activity for Gastrin I (human)
Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion and has a mitogenic effect on gastric cells. Gastrin stimulates gastric epithelial cell proliferation and histamine secretion (EC50 values are 6.2 pM and 0.014 nM, respectively). Gastrin I is also used in the culture of stomach, intestine and pancreas organoids. For more information about using Gastrin I in the generation of gastric organoids see the Human Gastric Organoid Culture Protocol.
Technical Data for Gastrin I (human)
(Modifications: X = Glp, Phe-17 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Gastrin I (human)
|Solubility||Soluble to 1 mg/ml in 1% Ammonia with sonication|
Product Datasheets for Gastrin I (human)
References for Gastrin I (human)
References are publications that support the biological activity of the product.
Noble et al (1999) International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol.Rev. 51 745 PMID: 10581329
Blandizzi et al (1999) CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur.J.Pharmacol. 373 71 PMID: 10408253
Sato et al (2015) SnapShot: Growing Organoids from Stem Cells. Cell 161 1700 PMID: 26091044
Mahe et al (2014) Establishment of gastrointestinal epithelial organoids Curr.Protoc. Mouse Biol. 3 217 PMID: 25105065
Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 126 PMID: 25307862
Kidd et al (2007) A comparison of the effects of gastrin, somatostatin and dopamine receptor ligands on rat gastric enterochromaffin-like cell secretion and proliferation. Regul.Pept. 143 109 PMID: 17531331
If you know of a relevant reference for Gastrin I (human), please let us know.
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Keywords: Gastrin I (human), Gastrin I (human) supplier, Selective, CCK2, agonists, Cholecystokinin2, Receptors, GastrinI, (human), organoids, gastric, histamine, Receptor, Organoids, 3006, Tocris Bioscience
6 Citations for Gastrin I (human)
Citations are publications that use Tocris products. Selected citations for Gastrin I (human) include:
Post et al (2020) Snake venom gland organoids. Cell 180 233 PMID: 31978343
Colomer et al (2019) IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Mol Cell 75 669 PMID: 31302002
Filippini et al (2019) Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease. Sci Rep 9 12286 PMID: 31439856
Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology. 148 126 PMID: 25307862
Roe et al (2017) Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell 170 875 PMID: 28757253
Somerville et al (2018) TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep 25 1741 PMID: 30428345
Do you know of a great paper that uses Gastrin I (human) from Tocris? Please let us know.
Reviews for Gastrin I (human)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.