Gastrin I (human)

Pricing Availability Delivery Time Qty
Cat.No. 3006 - Gastrin I (human) | Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 | CAS No. 10047-33-3
Description: Selective CCK2 agonist
Datasheet
Citations (1)
Literature

Biological Activity

Endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Stimulates gastric acid secretion.

Technical Data

M. Wt 2098.22
Formula C97H124N20O31S
Sequence XGPWLEEEEEAYGWMDF

(Modifications: X = Glp, Phe-17 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 10047-33-3
PubChem ID 16162108
InChI Key GKDWRERMBNGKCZ-RNXBIMIWSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 5% NH4OH

Preparing Stock Solutions

The following data is based on the product molecular weight 2098.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.48 mL 2.38 mL 4.77 mL
5 mM 0.1 mL 0.48 mL 0.95 mL
10 mM 0.05 mL 0.24 mL 0.48 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Noble et al (1999) International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol.Rev. 51 745 PMID: 10581329

Blandizzi et al (1999) CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur.J.Pharmacol. 373 71 PMID: 10408253


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Keywords: Gastrin I (human), supplier, Selective, CCK2, agonists, Cholecystokinin2, Receptors, GastrinI, (human), organoids, CCK2, Receptor, Tocris Bioscience

1 Citation for Gastrin I (human)

Citations are publications that use Tocris products. Selected citations for Gastrin I (human) include:

Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Front Cell Neurosci 148 126 PMID: 25307862


Do you know of a great paper that uses Gastrin I (human) from Tocris? If so please let us know.

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Literature in this Area

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Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Pathways for Gastrin I (human)

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