LY 288513

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Cat.No. 1524 - LY 288513 | C22H18BrN3O2 | CAS No. 147523-65-7
Description: Selective CCK2 antagonist
Chemical Name: (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively). Displays anxiolytic and antipsychotic properties in vivo.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data

M. Wt 436.3
Formula C22H18BrN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 147523-65-7
PubChem ID 2802894
InChI Key LMUQHXHWJWQXSD-PMACEKPBSA-N
Smiles BrC1=CC=C(NC(=O)N2NC(=O)[C@H]([C@@H]2C2=CC=CC=C2)C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.63 100
ethanol 43.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 436.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Rasmussen (1994) CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain dopamine neurons. Ann.N.Y.Acad.Sci. 713 300 PMID: 8185172

Helton et al (1996) Central nervous system characterization of the new cholecystokininB antagonist LY288513. Pharmacol.Biochem.Behav. 53 493 PMID: 8866946

Rasmussen et al (1992) Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain dopamine neurons. J.Pharmacol.Exp.Ther. 264 480 PMID:


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Keywords: LY 288513, supplier, Selective, CCK2, antagonists, Cholecystokinin2, Receptors, LY288513, CCK2, Receptor, CCK2, Receptor, Tocris Bioscience

1 Citation for LY 288513

Citations are publications that use Tocris products. Selected citations for LY 288513 include:

Wen et al (2012) Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence. Front Endocrinol (Lausanne) 13 63 PMID: 22682150


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