LY 288513

Pricing Availability   Qty
Description: Selective CCK2 antagonist
Chemical Name: (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for LY 288513

LY 288513 is a selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively). Displays anxiolytic and antipsychotic properties in vivo.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data for LY 288513

M. Wt 436.3
Formula C22H18BrN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 147523-65-7
PubChem ID 2802894
Smiles BrC1=CC=C(NC(=O)N2NC(=O)[C@H]([C@@H]2C2=CC=CC=C2)C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 288513

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.63 100

Preparing Stock Solutions for LY 288513

The following data is based on the product molecular weight 436.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for LY 288513

Certificate of Analysis / Product Datasheet
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References for LY 288513

References are publications that support the biological activity of the product.

Rasmussen (1994) CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain DA neurons. Ann.N.Y.Acad.Sci. 713 300 PMID: 8185172

Helton et al (1996) Central nervous system characterization of the new cholecystokininB antagonist LY288513. Pharmacol.Biochem.Behav. 53 493 PMID: 8866946

Rasmussen et al (1992) Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain DA neurons. J.Pharmacol.Exp.Ther. 264 480

If you know of a relevant reference for LY 288513, please let us know.

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Keywords: LY 288513, LY 288513 supplier, Selective, CCK2, antagonists, Cholecystokinin2, Receptors, LY288513, Receptor, 1524, Tocris Bioscience

1 Citation for LY 288513

Citations are publications that use Tocris products. Selected citations for LY 288513 include:

Wen et al (2012) Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular mor. dependence. Front Endocrinol (Lausanne) 13 63 PMID: 22682150

Do you know of a great paper that uses LY 288513 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.