SR 27897

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Cat.No. 2190 - SR 27897 | C20H14ClN3O3S | CAS No. 136381-85-6
Description: Potent and selective CCK1 antagonist
Alternative Names: Lintitript
Chemical Name: 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.

Compound Libraries

SR 27897 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 411.86
Formula C20H14ClN3O3S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 136381-85-6
PubChem ID 122077
InChI Key ILNRQFBVVQUOLP-UHFFFAOYSA-N
Smiles OC(=O)CN1C(=CC2=CC=CC=C12)C(=O)NC1=NC(=CS1)C1=CC=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.59 50

Preparing Stock Solutions

The following data is based on the product molecular weight 411.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.14 mL 24.28 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gouldson et al (1999) Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur.J.Pharmacol. 383 339 PMID: 10594328

Cano et al (2003) Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br.J.Pharmacol. 140 647 PMID: 14534148

Gully et al (1993) Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur.J.Pharmacol. 23 232 PMID:


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Keywords: SR 27897, supplier, Potent, selective, CCK1, antagonists, Cholecystokinin1, Receptors, CCK, Cholecystokinin, SR27897, Lintitript, CCK1, Receptor, CCK1, Receptor, Tocris Bioscience

1 Citation for SR 27897

Citations are publications that use Tocris products. Selected citations for SR 27897 include:

Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417


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