SR 27897

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Cat.No. 2190 - SR 27897 | C20H14ClN3O3S | CAS No. 136381-85-6
Description: Potent and selective CCK1 antagonist
Alternative Names: Lintitript
Chemical Name: 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

Potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.

Technical Data

M. Wt 411.86
Formula C20H14ClN3O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 136381-85-6
PubChem ID 122077
InChI Key ILNRQFBVVQUOLP-UHFFFAOYSA-N
Smiles OC(=O)CN1C(=CC2=CC=CC=C12)C(=O)NC1=NC(=CS1)C1=CC=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.59 50

Preparing Stock Solutions

The following data is based on the product molecular weight 411.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.86 mL 24.28 mL 48.56 mL
2.5 mM 0.97 mL 4.86 mL 9.71 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
25 mM 0.1 mL 0.49 mL 0.97 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Gouldson et al (1999) Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur.J.Pharmacol. 383 339 PMID: 10594328

Cano et al (2003) Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br.J.Pharmacol. 140 647 PMID: 14534148

Gully et al (1993) Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur.J.Pharmacol. 23 232


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Keywords: SR 27897, SR 27897 supplier, Potent, selective, CCK1, antagonists, Cholecystokinin1, Receptors, CCK, Cholecystokinin, SR27897, Lintitript, Receptor, 2190, Tocris Bioscience

1 Citation for SR 27897

Citations are publications that use Tocris products. Selected citations for SR 27897 include:

Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Peptides Involved in Appetite Modulation Scientific Review

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