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Biological Activity for A-71623
A-71623 is a potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.
Technical Data for A-71623
(Modifications: Trp-1 = Boc-Trp, Lys-3 = Lys(Tac), Phe-5 = N-methyl-Phe & C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A-71623
|Solubility||Soluble to 1 mg/ml in 20mM PBS buffer|
References for A-71623
References are publications that support the biological activity of the product.
Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699 PMID: 1513850
DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951
Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346
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Citations for A-71623
Citations are publications that use Tocris products.
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Reviews for A-71623
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.