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Description: Potent and selective CCK1 agonist; suppresses feeding
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for A-71623

A-71623 is a potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.

Technical Data for A-71623

M. Wt 840.97
Formula C44H56N8O9
Sequence WKDF

(Modifications: Trp-1 = Boc-Trp, Lys-2 = Lys(Tac), Phe-4 = N-methyl-Phe & C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 130408-77-4
PubChem ID 121964
Smiles O=C(N[C@H]([C@](N[C@@H](CC(O)=O)C(N(C)[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)CCCCNC(NC4=CC=CC=C4C)=O)[C@@H](NC(OC(C)(C)C)=O)CC1=CNC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A-71623

Solubility Soluble to 1 mg/ml in 20mM PBS buffer

Product Datasheets for A-71623

Certificate of Analysis / Product Datasheet
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References for A-71623

References are publications that support the biological activity of the product.

Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699 PMID: 1513850

DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951

Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346

If you know of a relevant reference for A-71623, please let us know.

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Keywords: A-71623, A-71623 supplier, Potent, selective, CCK1, agonists, Suppresses, feeding, Cholecystokinin1, Receptors, A71623, Receptor, 2411, Tocris Bioscience

Citations for A-71623

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.