Potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.
(Modifications: Trp-1 = Boc-Trp, Lys-3 = Lys(Tac), Phe-5 = N-methyl-Phe & C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 20mM PBS buffer|
Preparing Stock Solutions
The following data is based on the product molecular weight 840.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.19 mL||5.95 mL||11.89 mL|
|5 mM||0.24 mL||1.19 mL||2.38 mL|
|10 mM||0.12 mL||0.59 mL||1.19 mL|
|50 mM||0.02 mL||0.12 mL||0.24 mL|
References are publications that support the biological activity of the product.
Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699 PMID: 1513850
DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951
Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346
If you know of a relevant reference for A-71623, please let us know.
View Related Products by Product Action
Keywords: A-71623, A-71623 supplier, Potent, selective, CCK1, agonists, Suppresses, feeding, Cholecystokinin1, Receptors, A71623, Receptor, 2411, Tocris Bioscience
Citations for A-71623
Citations are publications that use Tocris products.
Currently there are no citations for A-71623. Do you know of a great paper that uses A-71623 from Tocris? Please let us know.
Reviews for A-71623
There are currently no reviews for this product. Be the first to review A-71623 and earn rewards!
Have you used A-71623?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.