Loxiglumide

Pricing Availability Delivery Time Qty
Cat.No. 3036 - Loxiglumide | C21H30Cl2N2O5 | CAS No. 107097-80-3
Description: CCK1 antagonist; active in vivo
Alternative Names: CR 1505
Chemical Name: 4-[(3,4-Dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxopentanoic acid
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

CCK1 antagonist. Suppresses CCK-induced proliferation of acinar cells. Inhibits pancreatic secretion of digestive enzymes. Active in vivo.

Technical Data

M. Wt 461.38
Formula C21H30Cl2N2O5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 107097-80-3
PubChem ID 60182
InChI Key QNQZBKQEIFTHFZ-UHFFFAOYSA-N
Smiles O=C(NC(CCC(O)=O)C(N(CCCOC)CCCCC)=O)C1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.14 100
ethanol 46.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 461.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.84 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Makovec et al (1986) New glutamic and aspartic derivatives with potent CCK-antagonistic activity. Eur. J. Med.Chem. 21 9

Kanemitsu et al (2006) Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats. Pancreas 32 190 PMID: 16552340

Nakano S et al (1995) Effect of the cholecystokinin receptor antagonist loxiglumide on pancreatic exocrine function in rats after acute pancreatitis. Pancreas 10 287 PMID: 7542770


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