Devazepide

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Cat.No. 2304 - Devazepide | C25H20N4O2 | CAS No. 103420-77-5
Description: Selective, orally active CCK1 receptor antagonist
Alternative Names: L-364,718, MK 329
Chemical Name: N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews (1)
Literature (3)

Biological Activity for Devazepide

Devazepide is a potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.

Technical Data for Devazepide

M. Wt 408.46
Formula C25H20N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 103420-77-5
PubChem ID 443375
InChI Key NFHRQQKPEBFUJK-HSZRJFAPSA-N
Smiles CN1C2=CC=CC=C2C(=N[C@H](NC(=O)C2=CC3=C(N2)C=CC=C3)C1=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Devazepide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.85 100
ethanol 20.42 50

Preparing Stock Solutions for Devazepide

The following data is based on the product molecular weight 408.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for Devazepide

Certificate of Analysis / Product Datasheet
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References for Devazepide

References are publications that support the biological activity of the product.

Ebenezer (2002) Effects of intracerebroventricular administration of the CCK1 receptor antagonist devazepide on food intake in rats. Eur.J.Pharmacol. 441 79 PMID: 12007923

Reidelberger et al (2003) Effects of peripheral CCK receptor blockade on food intake in rats. Am.J.Physiol.Reg.Integr.Comp.Physiol. 285 R429 PMID: 12738611

Ritter (2004) Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents. Am.J.Physiol.Reg.Integr.Comp.Physiol. 286 R991 PMID: 15142854

Duca et al (2015) MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat.Med. 21 506 PMID: 25849133


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Keywords: Devazepide, Devazepide supplier, Selective, orally, active, CCK1, receptor, antagonists, Cholecystokinin1, Receptors, L364718, MK329, L-364,718, MK, 329, Receptor, 2304, Tocris Bioscience

9 Citations for Devazepide

Citations are publications that use Tocris products. Selected citations for Devazepide include:

Bauer et al (2018) Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis. Cell Metab 27 572 PMID: 29514066

Blevins et al (2012) Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene. Am J Physiol Regul Integr Comp Physiol 303 R1231 PMID: 23115121

Blouet and Schwartz (2012) Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats. PLoS One 7 e51898 PMID: 23251649

Cheung et al (2009) Intestinal cholecystokinin controls glucose production through a neuronal network. Cell Metab 10 99 PMID: 19656488


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Reviews for Devazepide

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Works for block CCKA receptor..
By Donovan Argueta on 02/10/2021
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: CCK-eGFP-positive cells

We used low-fat chow fed mice and that is blocked by co-administration with the CCKA receptor antagonist by devazepide treatment.0.1 mg per kg for devazepide treatment

Devazepide was dissolved in vehicle consisting of 7.5% DMSO, 7.5% Tween80, and 85% sterile saline, and warmed in a water bath to ensure solubility.

Reference
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