Pricing Availability   Qty
Description: Selective, orally active CCK1 receptor antagonist
Alternative Names: L-364,718,MK 329
Chemical Name: N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
Purity: ≥99% (HPLC)
Citations (9)
Reviews (1)
Literature (1)

Biological Activity for Devazepide

Devazepide is a potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.

Technical Data for Devazepide

M. Wt 408.46
Formula C25H20N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 103420-77-5
PubChem ID 443375
Smiles CN1C2=CC=CC=C2C(=N[C@H](NC(=O)C2=CC3=C(N2)C=CC=C3)C1=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Devazepide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.85 100
ethanol 20.42 50

Preparing Stock Solutions for Devazepide

The following data is based on the product molecular weight 408.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for Devazepide

Certificate of Analysis / Product Datasheet
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References for Devazepide

References are publications that support the biological activity of the product.

Ebenezer (2002) Effects of intracerebroventricular administration of the CCK1 receptor antagonist devazepide on food intake in rats. Eur.J.Pharmacol. 441 79 PMID: 12007923

Reidelberger et al (2003) Effects of peripheral CCK receptor blockade on food intake in rats. Am.J.Physiol.Reg.Integr.Comp.Physiol. 285 R429 PMID: 12738611

Ritter (2004) Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents. Am.J.Physiol.Reg.Integr.Comp.Physiol. 286 R991 PMID: 15142854

Duca et al (2015) MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat.Med. 21 506 PMID: 25849133

If you know of a relevant reference for Devazepide, please let us know.

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Keywords: Devazepide, Devazepide supplier, Selective, orally, active, CCK1, receptor, antagonists, Cholecystokinin1, Receptors, L364718, MK329, L-364,718, MK, 329, Receptor, 2304, Tocris Bioscience

9 Citations for Devazepide

Citations are publications that use Tocris products. Selected citations for Devazepide include:

Schier et al (2011) Ongoing ingestive behavior is rapidly suppressed by a preabsorptive, intestinal "bitter taste" cue. Am J Physiol Regul Integr Comp Physiol 301 R1557 PMID: 21865540

Argueta et al (2019) Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity. Front Physiol 10 704 PMID: 31281260

Blouet and Schwartz (2012) Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats. PLoS One 7 e51898 PMID: 23251649

Cheung et al (2009) Intestinal cholecystokinin controls glucose production through a neuronal network. Cell Metab 10 99 PMID: 19656488

Do you know of a great paper that uses Devazepide from Tocris? Please let us know.

Reviews for Devazepide

Average Rating: 5 (Based on 1 Review.)

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Works for block CCKA receptor..
By Donovan Argueta on 02/10/2021
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: CCK-eGFP-positive cells

We used low-fat chow fed mice and that is blocked by co-administration with the CCKA receptor antagonist by devazepide treatment.0.1 mg per kg for devazepide treatment

Devazepide was dissolved in vehicle consisting of 7.5% DMSO, 7.5% Tween80, and 85% sterile saline, and warmed in a water bath to ensure solubility.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.