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Potent and selective noncompetitive AT1 receptor antagonist (IC50 = 37 nM). Reduces blood pressure in a rat model. Active metabolite of losartan potassium (Cat.No. 3798).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 436.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.29 mL||11.44 mL||22.89 mL|
|5 mM||0.46 mL||2.29 mL||4.58 mL|
|10 mM||0.23 mL||1.14 mL||2.29 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the biological activity of the product.
Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 255 211 PMID: 2213556
If you know of a relevant reference for EXP 3174, please let us know.
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Keywords: EXP 3174, EXP 3174 supplier, EXP3194, losartan, carboxylic, acid, metabolite, hypertension, antihypertensive, AT1, antagonists, antagonism, angiotensin, II, potent, noncompetitive, selective, Angiotensin, Receptors, 5728, Tocris Bioscience
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Peptide Hormone Receptors Product ListingUpdated
A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:
- Anterior Pituitary Regulation
- Blood Pressure Regulation
- Feeding and Appetite Regulation
- Glucose Regulation
- Peptide Hormone Processing