EXP 3174

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Description: Potent and selective AT1 antagonist
Chemical Name: 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity: ≥98% (HPLC)

Biological Activity for EXP 3174

EXP 3174 is a potent and selective noncompetitive AT1 receptor antagonist (IC50 = 37 nM). Reduces blood pressure in a rat model. Active metabolite of Losartan potassium (Cat. No. 3798).

Compound Libraries for EXP 3174

EXP 3174 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for EXP 3174

M. Wt 436.89
Formula C22H21ClN6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 124750-92-1
PubChem ID 108185
Smiles CCCCC1=NC(Cl)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EXP 3174

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.69 100
ethanol 43.69 100

Preparing Stock Solutions for EXP 3174

The following data is based on the product molecular weight 436.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.14 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for EXP 3174

References are publications that support the biological activity of the product.

Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 255 211 PMID: 2213556

If you know of a relevant reference for EXP 3174, please let us know.

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Keywords: EXP 3174, EXP 3174 supplier, EXP3194, losartan, carboxylic, acid, metabolite, hypertension, antihypertensive, AT1, antagonists, antagonism, angiotensin, II, potent, noncompetitive, selective, Angiotensin, Receptors, 5728, Tocris Bioscience

Citations for EXP 3174

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