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Irbesartan

Cat. No. 5798 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent AT1 antagonist
Chemical Name: 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Irbesartan

Irbesartan is a potent angiotensin II type 1 receptor (AT1) antagonist (IC50 = 1.3 nM). Displays antihypertensive activity. Orally bioavailable.

Compound Libraries for Irbesartan

Irbesartan is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Irbesartan

M. Wt 428.53
Formula C25H28N6O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 138402-11-6
PubChem ID 3749
InChI Key YOSHYTLCDANDAN-UHFFFAOYSA-N
Smiles O=C(C1(CCCC1)N=C2CCCC)N2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Irbesartan

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.85 100
ethanol 4.29 10

Preparing Stock Solutions for Irbesartan

The following data is based on the product molecular weight 428.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Irbesartan

References are publications that support the biological activity of the product.

Burnier et al (2001) Angiotensin II type 1 receptor blockers. Circulation 103 904 PMID: 11171802

If you know of a relevant reference for Irbesartan, please let us know.

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Citations for Irbesartan

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