Irbesartan
Biological Activity
Potent angiotensin II type 1 receptor (AT1) antagonist (IC50 = 1.3 nM). Displays antihypertensive activity. Orally bioavailable.
Compound Libraries
Irbesartan is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 428.53 |
| Formula | C25H28N6O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 138402-11-6 |
| PubChem ID | 3749 |
| InChI Key | YOSHYTLCDANDAN-UHFFFAOYSA-N |
| Smiles | O=C(C1(CCCC1)N=C2CCCC)N2CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.85 | 100 | |
| ethanol | 4.29 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 428.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Burnier et al (2001) Angiotensin II type 1 receptor blockers. Circulation 103 904 PMID: 11171802
If you know of a relevant reference for Irbesartan, please let us know.
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Keywords: Irbesartan, supplier, Potent, angiotensin, II, type, 1, receptor, antagonists, AT1, antihypertensive, orally, bioavailable, Angiotensin, AT1, Receptors, Angiotensin, AT1, Receptors, Tocris Bioscience
Citations for Irbesartan
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Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
