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Description: High affinity, selective AT1 antagonist
Alternative Names: CGP 48933
Chemical Name: (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid
Purity: ≥99% (HPLC)

Biological Activity for Valsartan

Valsartan is a high affinity AT1 receptor antagonist (Ki = 2.38 nM). Displays 30,000-fold selectivity over AT2 receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active.

Compound Libraries for Valsartan

Valsartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Valsartan

M. Wt 435.52
Formula C24H29N5O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 137862-53-4
PubChem ID 60846
Smiles CC(C)[C@@H]([C@@](O)=O)N(C(CCCC)=O)CC(C=C3)=CC=C3C1=CC=CC=C1C2=NN=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Valsartan

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.55 100

Preparing Stock Solutions for Valsartan

The following data is based on the product molecular weight 435.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for Valsartan

References are publications that support the biological activity of the product.

Criscione et al (1993) Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype. Br.J.Pharmacol. 110 761 PMID: 8242249

Wexler et al (1996) Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J.Med.Chem. 39 625 PMID: 8576904

Hanafy et al (2008) Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. Br.J.Pharmacol. 153 90 PMID: 17965735

If you know of a relevant reference for Valsartan, please let us know.

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Citations for Valsartan

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