Losartan potassium

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Cat.No. 3798 - Losartan potassium | C22H22ClKN6O | CAS No. 124750-99-8
Description: Selective, non-peptide AT1 antagonist
Alternative Names: DuP-753
Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (8)
Reviews (1)
Literature (4)

Biological Activity

Selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

Compound Libraries

Losartan potassium is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 461
Formula C22H22ClKN6O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 124750-99-8
PubChem ID 11476710
InChI Key OXCMYAYHXIHQOA-UHFFFAOYSA-N
Smiles CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.1 100
DMSO 46.1 100

Preparing Stock Solutions

The following data is based on the product molecular weight 461. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.85 mL 21.69 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Wong et al (1990) Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 255 584 PMID: 2243344

Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 252 719 PMID: 2179531

Rhaleb et al (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17 480 PMID: 1672862

Kuba et al (2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat.Med. 11 875 PMID: 16007097


If you know of a relevant reference for Losartan potassium, please let us know.

View Related Products by Product Action

View all Angiotensin AT1 Receptor Antagonists

Keywords: Losartan potassium, Losartan potassium supplier, Selective, non-peptide, angiotensin, II, A-II, AT1, receptors, antagonists, AT-II, DuP753, lung, injury, SARS-CoV, coronaviruses, DuP-753, Angiotensin, Receptors, COVID-19, 3798, Tocris Bioscience

8 Citations for Losartan potassium

Citations are publications that use Tocris products. Selected citations for Losartan potassium include:

Lee et al (2019) Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis. Sci Rep 9 12149 PMID: 31434946

Santhekadur et al (2014) Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling. FEBS Open Bio 4 353 PMID: 24918049

Thieme and Oliveira-Souza (2015) Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor. PLoS One 10 e0122265 PMID: 25793389

Dominska et al (2018) Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer. Sci.Rep. 8 15772 PMID: 30361641


Do you know of a great paper that uses Losartan potassium from Tocris? Please let us know.

Reviews for Losartan potassium

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Losartan as type 1 angiotensin II receptor antagonist in piglet study.
By Hiteshkumar Soni on 01/10/2018
Assay Type: In Vivo
Species: Other

We used Losartan as type 1 angiotensin II receptor antagonist in piglet study to prove that hUII-induced MAP elevation and hemodynamic changeswere inhibited by urantide, a UTR antagonist, but not with losartan.

PMID: 23554507
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