Losartan potassium

Pricing Availability   Qty
Description: Selective, non-peptide AT1 antagonist
Alternative Names: DuP-753
Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (15)
Reviews (1)

Biological Activity for Losartan potassium

Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

Compound Libraries for Losartan potassium

Losartan potassium is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Losartan potassium

M. Wt 461
Formula C22H22ClKN6O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 124750-99-8
PubChem ID 11476710
InChI Key OXCMYAYHXIHQOA-UHFFFAOYSA-N
Smiles CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Losartan potassium

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.1 100
DMSO 46.1 100

Preparing Stock Solutions for Losartan potassium

The following data is based on the product molecular weight 461. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.85 mL 21.69 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets for Losartan potassium

Certificate of Analysis / Product Datasheet
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References for Losartan potassium

References are publications that support the biological activity of the product.

Wong et al (1990) Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 255 584 PMID: 2243344

Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 252 719 PMID: 2179531

Rhaleb et al (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17 480 PMID: 1672862

Kuba et al (2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat.Med. 11 875 PMID: 16007097


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Keywords: Losartan potassium, Losartan potassium supplier, Selective, non-peptide, angiotensin, II, A-II, AT1, receptors, antagonists, AT-II, DuP753, lung, injury, SARS-CoV, coronaviruses, DuP-753, Angiotensin, Receptors, COVID-19, 3798, Tocris Bioscience

15 Citations for Losartan potassium

Citations are publications that use Tocris products. Selected citations for Losartan potassium include:

Ariel et al (2021) Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts. Cells 10 PMID: 33922850

Moreno-Santos et al (2021) Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats. Behav.Brain Res. 397 PMID: 33011187

Tsai et al (2012) Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. EMBO Mol Med 7 e33527 PMID: 22442695

Santhekadur et al (2014) Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling. FEBS Open Bio 4 353 PMID: 24918049

Dominska et al (2018) Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer. Sci.Rep. 8 15772 PMID: 30361641

Thieme and Oliveira-Souza (2015) Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor. PLoS One 10 e0122265 PMID: 25793389

Justin et al (2022) Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids. iScience 25 103818 PMID: 35106453

Bhattachariya et al (2014) PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle. Physiol Rep 2 PMID: 25347863

Lee et al (2019) Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis. Sci Rep 9 12149 PMID: 31434946

Swen et al (2023) Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling. Front Cell Neurosci 17 1111263 PMID: 36816850

Diego et al (2020) The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Sci Signal 13 PMID: 32753479

Tomasz et al (2020) The Impact of Ang-(1-9) and Ang-(3-7) on the Biological Properties of Prostate Cancer Cells by Modulation of Inflammatory and Steroidogenesis Pathway Genes. Int J Mol Sci 21 PMID: 32872192

Leite-Moreira et al (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147 690 PMID: 16415904

Fang et al (2013) Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice. Am J Physiol Heart Circ Physiol 304 H816 PMID: 23292716

Eero et al (2018) Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN. Neuropharmacology 135 163-171 PMID: 29550391


Do you know of a great paper that uses Losartan potassium from Tocris? Please let us know.

Reviews for Losartan potassium

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Losartan as type 1 angiotensin II receptor antagonist in piglet study.
By Hiteshkumar Soni on 01/10/2018
Assay Type: In Vivo
Species: Other

We used Losartan as type 1 angiotensin II receptor antagonist in piglet study to prove that hUII-induced MAP elevation and hemodynamic changeswere inhibited by urantide, a UTR antagonist, but not with losartan.

PMID: 23554507
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