Losartan potassium

Pricing Availability   Qty
Description: Selective, non-peptide AT1 antagonist
Alternative Names: DuP-753
Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt
Purity: ≥99% (HPLC)
Citations (9)
Reviews (1)
Literature (4)

Biological Activity for Losartan potassium

Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

Compound Libraries for Losartan potassium

Losartan potassium is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Losartan potassium

M. Wt 461
Formula C22H22ClKN6O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 124750-99-8
PubChem ID 11476710
Smiles CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Losartan potassium

Solvent Max Conc. mg/mL Max Conc. mM
water 46.1 100
DMSO 46.1 100

Preparing Stock Solutions for Losartan potassium

The following data is based on the product molecular weight 461. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.85 mL 21.69 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets for Losartan potassium

Certificate of Analysis / Product Datasheet
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References for Losartan potassium

References are publications that support the biological activity of the product.

Wong et al (1990) Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 255 584 PMID: 2243344

Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 252 719 PMID: 2179531

Rhaleb et al (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17 480 PMID: 1672862

Kuba et al (2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat.Med. 11 875 PMID: 16007097

If you know of a relevant reference for Losartan potassium, please let us know.

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Keywords: Losartan potassium, Losartan potassium supplier, Selective, non-peptide, angiotensin, II, A-II, AT1, receptors, antagonists, AT-II, DuP753, lung, injury, SARS-CoV, coronaviruses, DuP-753, Angiotensin, Receptors, COVID-19, 3798, Tocris Bioscience

9 Citations for Losartan potassium

Citations are publications that use Tocris products. Selected citations for Losartan potassium include:

Moreno-Santos et al (2021) Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats. Behav.Brain Res. 397 PMID: 33011187

Tsai et al (2012) Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. EMBO Mol Med 7 e33527 PMID: 22442695

Bhattachariya et al (2014) PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle. Physiol Rep 2 PMID: 25347863

Leite-Moreira et al (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147 690 PMID: 16415904

Do you know of a great paper that uses Losartan potassium from Tocris? Please let us know.

Reviews for Losartan potassium

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Losartan as type 1 angiotensin II receptor antagonist in piglet study.
By Hiteshkumar Soni on 01/10/2018
Assay Type: In Vivo
Species: Other

We used Losartan as type 1 angiotensin II receptor antagonist in piglet study to prove that hUII-induced MAP elevation and hemodynamic changeswere inhibited by urantide, a UTR antagonist, but not with losartan.

PMID: 23554507
review image

Literature in this Area

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