Losartan potassium
Biological Activity
Selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent.
Compound Libraries
Losartan potassium is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 461 |
| Formula | C22H22ClKN6O |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 124750-99-8 |
| PubChem ID | 11476710 |
| InChI Key | OXCMYAYHXIHQOA-UHFFFAOYSA-N |
| Smiles | CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.1 | 100 | |
| water | 46.1 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 461. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.85 mL | 21.69 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wong et al (1990) Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 255 584 PMID: 2243344
Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 252 719 PMID: 2179531
Rhaleb et al (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17 480 PMID: 1672862
If you know of a relevant reference for Losartan potassium, please let us know.
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Keywords: Losartan potassium, supplier, Selective, non-peptide, angiotensin, II, A-II, AT1, receptors, antagonists, AT-II, DuP753, DuP-753, Angiotensin, AT1, Receptors, Tocris Bioscience
5 Citations for Losartan potassium
Citations are publications that use Tocris products. Selected citations for Losartan potassium include:
Thieme and Oliveira-Souza (2015) Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor. PLoS One 10 e0122265 PMID: 25793389
Santhekadur et al (2014) Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling. FEBS Open Bio 4 353 PMID: 24918049
Fang et al (2013) Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice. Am J Physiol Heart Circ Physiol 304 H816 PMID: 23292716
Tsai et al (2012) Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. EMBO Mol Med 7 e33527 PMID: 22442695
Leite-Moreira et al (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147 690 PMID: 16415904
Do you know of a great paper that uses Losartan potassium from Tocris? If so please let us know.
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