Phosphoinositide-dependent Kinase 1

Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the function of the PI 3-K/Akt signaling pathway. PDPK1 and mTORC2 both phosphorylate and activate PKB/Akt, ensuring a cellular response to growth factors and insulin signaling.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3606 BAG 956
Dual PDPK1 (PDK1) and PI 3-kinase inhibitor
4318 BX 795
PDPK1 (PDK1) inhibitor
4143 GSK 2334470
Highly potent, selective PDPK1 (PDK1) inhibitor
5682 OSU 03012
PDPK1 (PDK1) inhibitor; inhibits Akt signaling
4598 PHT 427
Dual Akt and PDPK1 (PDK1) inhibitor; antitumor

Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the function of the PI 3-K/Akt signaling pathway. PDPK1 and mTORC2 both phosphorylate and activate PKB/Akt, ensuring a cellular response to stimuli such as growth factors and insulin signaling. Akt is the main effector of PDPK1.

PDPK1 also phosphorylates several members of the AGC (automatic gain control) family of protein kinases. PDPK1 phosphorylates substrates either constitutively or in response to a cellular agonist.

Literature for Phosphoinositide-dependent Kinase 1

Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Phosphoinositide-dependent Kinase 1 Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PDK1 Human PDK1 NM_002610 Q15118
Mouse Pdk1 NM_172665 Q8BFP9
Rat Pdk1 NM_053826 Q63065