Cat. No. 3101
Chemical Name: 1-(3-Chlorophenyl)-4-[(3-methyl-1-p
Biological ActivityRas-Net (Elk-3) pathway inhibitor (IC50 = 10 - 20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2-M cell cycle arrest, suppresses growth of multiple cell types (IC50 ~ 2 nM), inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wasylyk et al (2008) Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res. 68 1275. PMID: 18316589.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses XRP44X from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: XRP44X, supplier, Ras-Net, pathway, inhibitors, Antiangiogenics, microtubule, depolymerization, depolymerisation, agent, MAPK, Signaling, Signalling, G, Proteins, Small, Mitogen-Activated, Protein, Kinases, Tau, Tubulin, Tocris Bioscience, Other MAPK Inhibitor products
Find multiple products by catalog number
New Products in this Area
High affinity and selective p38 kinase inhibitorPH 797804
Potent and selective p38α/β inhibitorDEL 22379
ERK dimerization inhibitorPF 06260933 dihydrochloride
MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for ASCB 2016.