NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 62.4 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.84 mL||19.22 mL||38.44 mL|
|5 mM||0.77 mL||3.84 mL||7.69 mL|
|10 mM||0.38 mL||1.92 mL||3.84 mL|
|50 mM||0.08 mL||0.38 mL||0.77 mL|
References are publications that support the biological activity of the product.
Holtman et al (2008) Effects of norketamine enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676 PMID: 18586315
Singh et al (2016) Ketamine metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720
If you know of a relevant reference for (S)-Norketamine hydrochloride, please let us know.
View Related Products by Target
Keywords: (S)-Norketamine hydrochloride, (S)-Norketamine hydrochloride supplier, NMDA, modulators, modulates, analgesic, ketamine, metabolites, Receptors, Ketamine, and, Metabolites, 6112, Tocris Bioscience
Citations for (S)-Norketamine hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for (S)-Norketamine hydrochloride. Do you know of a great paper that uses (S)-Norketamine hydrochloride from Tocris? Please let us know.
Reviews for (S)-Norketamine hydrochloride
There are currently no reviews for this product. Be the first to review (S)-Norketamine hydrochloride and earn rewards!
Have you used (S)-Norketamine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.