(S)-Norketamine hydrochloride

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Cat.No. 6112 - (S)-Norketamine hydrochloride | C12H14ClNO.HCl | CAS No. 83777-70-2
Description: NMDA receptor modulator; analgesic
Chemical Name: (S)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 62.4 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.

R-enantiomer and racemate also available.

Technical Data

M. Wt 260.16
Formula C12H14ClNO.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 83777-70-2
PubChem ID 71743704
Smiles ClC1=C([C@]2(N)C(CCCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 26.02 100
DMSO 26.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.84 mL 19.22 mL 38.44 mL
5 mM 0.77 mL 3.84 mL 7.69 mL
10 mM 0.38 mL 1.92 mL 3.84 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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References are publications that support the biological activity of the product.

Holtman et al (2008) Effects of norKA enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676 PMID: 18586315

Singh et al (2016) KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720

If you know of a relevant reference for (S)-Norketamine hydrochloride, please let us know.

Keywords: (S)-Norketamine hydrochloride, (S)-Norketamine hydrochloride supplier, NMDA, modulators, modulates, analgesic, ketamine, metabolites, Receptors, Ketamine, and, Metabolites, 6112, Tocris Bioscience

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Literature in this Area

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Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.