(S)-Norketamine hydrochloride

Pricing Availability   Qty
Description: NMDA receptor modulator; analgesic
Chemical Name: (S)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for (S)-Norketamine hydrochloride

(S)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 62.4 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.

R-enantiomer and racemate also available.

Technical Data for (S)-Norketamine hydrochloride

M. Wt 260.16
Formula C12H14ClNO.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 83777-70-2
PubChem ID 71743704
Smiles ClC1=C([C@]2(N)C(CCCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (S)-Norketamine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 26.02 100
DMSO 26.02 100

Preparing Stock Solutions for (S)-Norketamine hydrochloride

The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.84 mL 19.22 mL 38.44 mL
5 mM 0.77 mL 3.84 mL 7.69 mL
10 mM 0.38 mL 1.92 mL 3.84 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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Product Datasheets for (S)-Norketamine hydrochloride

References for (S)-Norketamine hydrochloride

References are publications that support the biological activity of the product.

Holtman et al (2008) Effects of norKA enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676 PMID: 18586315

Singh et al (2016) KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720

If you know of a relevant reference for (S)-Norketamine hydrochloride, please let us know.

Keywords: (S)-Norketamine hydrochloride, (S)-Norketamine hydrochloride supplier, NMDA, modulators, modulates, analgesic, ketamine, metabolites, Receptors, Ketamine, and, Metabolites, 6112, Tocris Bioscience

1 Citation for (S)-Norketamine hydrochloride

Citations are publications that use Tocris products. Selected citations for (S)-Norketamine hydrochloride include:

Ago et al (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol 22 665 PMID: 31325908

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Literature in this Area

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