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(S)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 62.4 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.
R-enantiomer and racemate also available.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.84 mL||19.22 mL||38.44 mL|
|5 mM||0.77 mL||3.84 mL||7.69 mL|
|10 mM||0.38 mL||1.92 mL||3.84 mL|
|50 mM||0.08 mL||0.38 mL||0.77 mL|
References are publications that support the biological activity of the product.
Holtman et al (2008) Effects of norKA enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676 PMID: 18586315
Singh et al (2016) KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720
If you know of a relevant reference for (S)-Norketamine hydrochloride, please let us know.
Keywords: (S)-Norketamine hydrochloride, (S)-Norketamine hydrochloride supplier, NMDA, modulators, modulates, analgesic, ketamine, metabolites, Receptors, Ketamine, and, Metabolites, 6112, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for (S)-Norketamine hydrochloride include:
Ago et al (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol 22 665 PMID: 31325908
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.