Non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for NR1/NR2A and NR1/NR2B subunit combinations respectively). Dissociative anesthetic.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.65 mL||18.24 mL||36.47 mL|
|5 mM||0.73 mL||3.65 mL||7.29 mL|
|10 mM||0.36 mL||1.82 mL||3.65 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References are publications that support the products' biological activity.
Anis et al (1983) The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565 PMID: 6317114
Pallares et al (1995) Effects of ketamine, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389 PMID: 7716221
If you know of a relevant reference for Ketamine hydrochloride, please let us know.
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Keywords: Ketamine hydrochloride, supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Dissociative, anesthetic, NMDA, Receptors, Ketamine, and, Metabolites, Ketamine, and, Metabolites, Tocris Bioscience
1 Citation for Ketamine hydrochloride
Citations are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:
Rzeski et al (2001) Glutamate antagonists limit tumor growth. Oncotarget 98 6372 PMID: 11331750
Do you know of a great paper that uses Ketamine hydrochloride from Tocris? If so please let us know.
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