Ketamine hydrochloride

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Cat.No. 3131 - Ketamine hydrochloride | C13H16ClNO.HCl | CAS No. 1867-66-9
Description: Non-competitive NMDA receptor antagonist
Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for GluN1/GluN2A (formally NR1 and NR2A, respectively) and GluN1/GluN2B (formally NR1 and NR2B, respectively) subunit combinations respectively). Dissociative anesthetic.

S-enantiomer and Active metabolite also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions. .

Technical Data

M. Wt 274.19
Formula C13H16ClNO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1867-66-9
PubChem ID 15851
InChI Key VCMGMSHEPQENPE-UHFFFAOYSA-N
Smiles O=C1C(C2=CC=CC=C2Cl)(NC)CCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.24 mL 36.47 mL
5 mM 0.73 mL 3.65 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.65 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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References

References are publications that support the biological activity of the product.

Anis et al (1983) The dissociative anaesthetics, KA and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565 PMID: 6317114

Pallares et al (1995) Effects of KA, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389 PMID: 7716221

Liu et al (2001) Modulation of NMDA receptor function by KA and magnesium: part I. Anesth.Pharmacol. 92 1173


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1 Citation for Ketamine hydrochloride

Citations are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:

Rzeski et al (2001) Glutamate antagonists limit tumor growth. Oncotarget 98 6372 PMID: 11331750


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Literature in this Area

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