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Non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for GluN1/GluN2A (formally NR1 and NR2A, respectively) and GluN1/GluN2B (formally NR1 and NR2B, respectively) subunit combinations respectively). Dissociative anesthetic.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions. .
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.65 mL||18.24 mL||36.47 mL|
|5 mM||0.73 mL||3.65 mL||7.29 mL|
|10 mM||0.36 mL||1.82 mL||3.65 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References are publications that support the biological activity of the product.
Anis et al (1983) The dissociative anaesthetics, KA and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565 PMID: 6317114
Pallares et al (1995) Effects of KA, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389 PMID: 7716221
Liu et al (2001) Modulation of NMDA receptor function by KA and magnesium: part I. Anesth.Pharmacol. 92 1173
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1 Citation for Ketamine hydrochloride
Citations are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:
Rzeski et al (2001) Glutamate antagonists limit tumor growth. Oncotarget 98 6372 PMID: 11331750
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.