Ketamine hydrochloride

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Cat.No. 3131 - Ketamine hydrochloride | C13H16ClNO.HCl | CAS No. 1867-66-9
Description: Non-competitive NMDA receptor antagonist
Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Non-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for NR1/NR2A and NR1/NR2B subunit combinations respectively). Dissociative anesthetic.

S-enantiomer and Active metabolite also available.

Technical Data

M. Wt 274.19
Formula C13H16ClNO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1867-66-9
PubChem ID 15851
Smiles O=C1C(C2=CC=CC=C2Cl)(NC)CCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 27.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.24 mL 36.47 mL
5 mM 0.73 mL 3.65 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.65 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Anis et al (1983) The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565 PMID: 6317114

Pallares et al (1995) Effects of ketamine, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389 PMID: 7716221

Liu et al (2001) Modulation of NMDA receptor function by ketamine and magnesium: part I. Anesth.Pharmacol. 92 1173 PMID:

If you know of a relevant reference for Ketamine hydrochloride, please let us know.

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1 Citation for Ketamine hydrochloride

Citations are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:

Rzeski et al (2001) Glutamate antagonists limit tumor growth. Oncotarget 98 6372 PMID: 11331750

Do you know of a great paper that uses Ketamine hydrochloride from Tocris? If so please let us know.

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