Norketamine hydrochloride

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Cat.No. 1970 - Norketamine hydrochloride | C12H14ClNO.HCl | CAS No. 79499-59-5
Description: Potent non-competitive NMDA antagonist; antinociceptive
Chemical Name: 2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo.

R-enantiomer and S-enantiomer also available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 260.16
Formula C12H14ClNO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 79499-59-5
PubChem ID 25195026
InChI Key CLPOJGPBUGCUKT-UHFFFAOYSA-N
Smiles Cl.NC1(CCCCC1=O)C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.84 mL 19.22 mL 38.44 mL
5 mM 0.77 mL 3.84 mL 7.69 mL
10 mM 0.38 mL 1.92 mL 3.84 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Leung et al (1986) Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA. J.Med.Chem. 29 2396 PMID: 3783598

Ebert et al (1997) NorKA, the main metabolite of KA, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 333 99 PMID: 9311667

Shimoyama et al (1999) Oral KA is antinociceptive in the rat formalin test: role of the metabolite, norKA. Pain 81 85 PMID: 10353496


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Citations for Norketamine hydrochloride

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Literature in this Area

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