Norketamine hydrochloride

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Cat.No. 1970 - Norketamine hydrochloride | C12H14ClNO.HCl | CAS No. 79499-59-5
Description: Potent, non-competitive NMDA antagonist; antinociceptive
Chemical Name: 2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo. R-enantiomer and S-enantiomer also available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 260.16
Formula C12H14ClNO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 79499-59-5
PubChem ID 25195026
InChI Key CLPOJGPBUGCUKT-UHFFFAOYSA-N
Smiles Cl.NC1(CCCCC1=O)C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 26.02 100
water 26.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.84 mL 19.22 mL 38.44 mL
5 mM 0.77 mL 3.84 mL 7.69 mL
10 mM 0.38 mL 1.92 mL 3.84 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Leung et al (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396 PMID: 3783598

Ebert et al (1997) Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 333 99 PMID: 9311667

Shimoyama et al (1999) Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. Pain 81 85 PMID: 10353496


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Citations for Norketamine hydrochloride

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