Norketamine hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 1970 - Norketamine hydrochloride | C12H14ClNO.HCl | CAS No. 79499-59-5
Description: Potent, non-competitive NMDA antagonist; antinociceptive
Chemical Name: 2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo.

R-enantiomer and S-enantiomer also available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 260.16
Formula C12H14ClNO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 79499-59-5
PubChem ID 25195026
Smiles Cl.NC1(CCCCC1=O)C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 26.02 100
phosphate buffered saline 26.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.84 mL 19.22 mL 38.44 mL
5 mM 0.77 mL 3.84 mL 7.69 mL
10 mM 0.38 mL 1.92 mL 3.84 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Leung et al (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396 PMID: 3783598

Ebert et al (1997) Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 333 99 PMID: 9311667

Shimoyama et al (1999) Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. Pain 81 85 PMID: 10353496

If you know of a relevant reference for Norketamine hydrochloride, please let us know.

Keywords: Norketamine hydrochloride, supplier, Potent, non-competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Pfizer, NMDA, Receptors, Ketamine, and, Metabolites, Ketamine, and, Metabolites, Tocris Bioscience

Citations for Norketamine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Norketamine hydrochloride. Do you know of a great paper that uses Norketamine hydrochloride from Tocris? If so please let us know.

Reviews for Norketamine hydrochloride

There are currently no reviews for this product. Be the first to review Norketamine hydrochloride and earn rewards!

Have you used Norketamine hydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.