(R)-Norketamine hydrochloride

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Cat.No. 5996 - (R)-Norketamine hydrochloride | C12H14ClNO.HCl | CAS No. 83777-68-8
Description: NMDA receptor modulator; analgesic
Chemical Name: (R)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

NMDA receptor modulator. Metabolite of Ketamine hydrochloride (Cat. No.3131). Decreases intracellular D-serine concentration (IC50 = 91 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models. S-enantiomer and racemate also available.

Technical Data

M. Wt 260.16
Formula C12H14ClNO.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 83777-68-8
PubChem ID 71743680
Smiles ClC1=C([C@@]2(N)C(CCCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.02 100
water 26.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.84 mL 19.22 mL 38.44 mL
5 mM 0.77 mL 3.84 mL 7.69 mL
10 mM 0.38 mL 1.92 mL 3.84 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Singh et al (2016) Ketamine metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720

Holtman et al (2008) Effects of norketamine enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676 PMID: 18586315

If you know of a relevant reference for (R)-Norketamine hydrochloride, please let us know.

Keywords: (R)-Norketamine hydrochloride, supplier, NMDA, modulators, modulates, analgesic, ketamine, metabolites, NMDA, Receptors, Ketamine, and, Metabolites, Ketamine, and, Metabolites, Tocris Bioscience

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