NMDA receptor modulator. Metabolite of Ketamine hydrochloride (Cat. No.3131). Decreases intracellular D-serine concentration (IC50 = 91 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models. S-enantiomer and racemate also available.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.84 mL||19.22 mL||38.44 mL|
|5 mM||0.77 mL||3.84 mL||7.69 mL|
|10 mM||0.38 mL||1.92 mL||3.84 mL|
|50 mM||0.08 mL||0.38 mL||0.77 mL|
References are publications that support the products' biological activity.
Singh et al (2016) Ketamine metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720
Holtman et al (2008) Effects of norketamine enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676 PMID: 18586315
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