Fendiline Hydrochloride

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Cat.No. 6407 - Fendiline Hydrochloride | C23H25N.HCl | CAS No. 13636-18-5
Description: Inhibits K-Ras localization to the plasma membrane; also L-type calcium channel blocker
Chemical Name: N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

K-Ras inhibitor. Selectively inhibits K-Ras localization to the plasma membrane (IC50 = 9.64 μM). Blocks proliferation of cancer cell lines expressing oncogenic mutant K-Ras. Also inhibits L-type calcium channels (IC50 = 17 μM).

Technical Data

M. Wt 351.91
Formula C23H25N.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 13636-18-5
PubChem ID 5702162
InChI Key NJXWZWXCHBNOOG-UHFFFAOYSA-N
Smiles CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.19 100
ethanol 7.04 20

Preparing Stock Solutions

The following data is based on the product molecular weight 351.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Tripathi et al (1993) Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Br.J.Pharmacol. 108 865 PMID: 8485628

van der Hoeven et al (2015) Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol.Cell.Biol. 33 237 PMID: 23129805


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Keywords: Fendiline Hydrochloride, Fendiline Hydrochloride supplier, K-Ras, membrane, localization, inhibitors, inhibits, L-type, calcium, channel, Ca2+, voltage-gated, Cav, blockers, blocks, Voltage-gated, Calcium, Channels, Ras, 6407, Tocris Bioscience

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