K-Ras inhibitor. Selectively inhibits K-Ras localization to the plasma membrane (IC50 = 9.64 μM). Blocks proliferation of cancer cell lines expressing oncogenic mutant K-Ras. Also inhibits L-type calcium channels (IC50 = 17 μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 351.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.84 mL||14.21 mL||28.42 mL|
|5 mM||0.57 mL||2.84 mL||5.68 mL|
|10 mM||0.28 mL||1.42 mL||2.84 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References are publications that support the products' biological activity.
Tripathi et al (1993) Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study. Br.J.Pharmacol. 108 865 PMID: 8485628
van der Hoeven et al (2015) Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol.Cell.Biol. 33 237 PMID: 23129805
If you know of a relevant reference for Fendiline Hydrochloride, please let us know.
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Keywords: Fendiline Hydrochloride, supplier, K-Ras, membrane, localization, inhibitors, inhibits, L-type, calcium, channel, Ca2+, voltage-gated, Cav, blockers, blocks, GTPase, Voltage-gated, Calcium, Channels, G, Proteins, (Small), GTPase, Tocris Bioscience
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