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Biological Activity for CCG 1423
CCG 1423 is a Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.
Compound Libraries for CCG 1423
Technical Data for CCG 1423
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CCG 1423
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CCG 1423
The following data is based on the product molecular weight 454.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||11 mL||21.99 mL|
|5 mM||0.44 mL||2.2 mL||4.4 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References for CCG 1423
References are publications that support the biological activity of the product.
Mae et al (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem.Biophys.Res.Commun. 393 877 PMID: 20171952
Evelyn et al (2007) CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol.Cancer Ther. 6 2249 PMID: 17699722
If you know of a relevant reference for CCG 1423, please let us know.
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Keywords: CCG 1423, CCG 1423 supplier, CCG1423, Rho, SRF, pathway, inhibitors, inhibits, intermediate, mesoderm, differentiation, ESC, embryonic, stem, cells, serum, response, factors, cancer, ESCs, and, iPSC, 5233, Tocris Bioscience
4 Citations for CCG 1423
Citations are publications that use Tocris products. Selected citations for CCG 1423 include:
Preet M et al (2020) Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma. Sci Rep 10 5712 PMID: 32235878
Aarthi et al (2021) Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3. Viruses 13 PMID: 34452398
Li et al (2021) Regulation of the Muscarinic M3 Receptor by Myocardin-Related Transcription Factors. Front Physiol 12 710968 PMID: 34539433
Li et al (2021) Cell Type Dependent Suppression of Inflammatory Mediators by Myocardin Related Transcription Factors. Front Physiol 12 732564 PMID: 34671275
Do you know of a great paper that uses CCG 1423 from Tocris? Please let us know.
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