CCG 1423

Pricing Availability Delivery Time Qty
Cat.No. 5233 - CCG 1423 | C18H13ClF6N2O3 | CAS No. 285986-88-1
Description: Induces intermediate mesoderm differentiation from ESCs; Rho/SRF pathway inhibitor
Chemical Name: N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.

Compound Libraries

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Technical Data

M. Wt 454.75
Formula C18H13ClF6N2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 285986-88-1
PubChem ID 2726015
InChI Key DSMXVSGJIDFLKP-UHFFFAOYSA-N
Smiles O=C(NOC(C)C(NC2=CC=C(Cl)C=C2)=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.48 100
ethanol 4.55 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 454.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11 mL 21.99 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mae et al (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem.Biophys.Res.Commun. 393 877 PMID: 20171952

Evelyn et al (2007) CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol.Cancer Ther. 6 2249 PMID: 17699722


If you know of a relevant reference for CCG 1423, please let us know.

Keywords: CCG1423 Rho SRF pathway inhibitors inhibits intermediate mesoderm differentiation ESC embryonic stem cells serum response factors cancer ESCs and iPSC

Citations for CCG 1423

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for CCG 1423

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