Home / Product Type / PROTAC® Degraders & Targeted Protein Degradation / Degrader Building Blocks / LYTAC Building Blocks

LYTAC Building Blocks

LYTAC Building Blocks provide an advanced starting point for LYTAC development. LYTAC (LYsosome TArgeting Chimera) molecules are a new approach to Targeted Protein Degradation, which direct an extracellular protein of interest to the lysosome for degradation. LYTACs are heterobifunctional molecules comprising a recruiting molecule for a target protein (e.g. an antibody) joined by a linker to a ligand for a cell surface receptor, such as the cation-independent mannose-6-phosphate receptor (CI-M6PR) or the asialoglycoprotein receptor (ASGPR). The LYTAC forms a ternary complex with the protein of interest and the receptor, triggering internalization of the target protein via endocytosis and its subsequent lysosomal degradation.

Products
Literature (2)

Building Blocks
Cat. No. Product Name / Activity
8042 Alkyne-cRGD
Integrin ligand with alkyne handle for LYTAC Degrader development
7780 β-GalNAc-PEG4-Azide
Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
7635 tri-GalNAc biotin
Biotinylated ASGPR ligand for LYTAC research and development
7401 tri-GalNAc COOH
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
7781 tri-GalNAc-C5-amine
Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
8015 tri-GalNAc-PEG3-Azide
Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Other
Cat. No. Product Name / Activity
8828 Angiopep-2
Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB
8829 TransMoDE 3 Biotin
Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines
7901 tri-GalNAc-C5-AF647
Fluorescent asialoglycoprotein receptor ligand

Literature for LYTAC Building Blocks

Tocris offers the following scientific literature for LYTAC Building Blocks to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia