- Cell Biology
- Product Type
- Research Area
- New Products
- About Tocris
- Contact Us
LYTAC Building Blocks provide an advanced starting point for LYTAC development. LYTAC (LYsosome TArgeting Chimera) molecules are a new approach to Targeted Protein Degradation, which direct an extracellular protein of interest to the lysosome for degradation. LYTACs are heterobifunctional molecules comprising a recruiting molecule for a target protein (e.g. an antibody) joined by a linker to a ligand for a cell surface receptor, such as the cation-independent mannose-6-phosphate receptor (CI-M6PR) or the asialoglycoprotein receptor (ASGPR). The LYTAC forms a ternary complex with the protein of interest and the receptor, triggering internalization of the target protein via endocytosis and its subsequent lysosomal degradation.
|Cat. No.||Product Name / Activity|
|Biotinylated ASGPR ligand for LYTAC research and development|
|Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry|
|Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry|
Tocris offers the following scientific literature for LYTAC Building Blocks to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia