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Biological Activity for tri-GalNAc-PEG3-Azide
tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.
Technical Data for tri-GalNAc-PEG3-Azide
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for tri-GalNAc-PEG3-Azide
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for tri-GalNAc-PEG3-Azide
The following data is based on the product molecular weight 1644.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.04 mM||15.2 mL||76 mL||151.99 mL|
|0.2 mM||3.04 mL||15.2 mL||30.4 mL|
|0.4 mM||1.52 mL||7.6 mL||15.2 mL|
|2 mM||0.3 mL||1.52 mL||3.04 mL|
Product Datasheets for tri-GalNAc-PEG3-Azide
References for tri-GalNAc-PEG3-Azide
References are publications that support the biological activity of the product.
Sanhueza et al (2017) Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 139 3528 PMID: 28230359
If you know of a relevant reference for tri-GalNAc-PEG3-Azide, please let us know.
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Citations for tri-GalNAc-PEG3-Azide
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Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
- Assays for Protein Degradation
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia