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Description: Fluorescent ASGPR ligand. Application: flow cytometry, fluorescence microscopy
Purity: ≥90%

Biological Activity for tri-GalNAc-C5-AF647

Key information: tri-GalNAc-C5-AF647 is a fluorescent asialoglycoprotein receptor (ASGPR) ligand. Suitable for live-cell imaging. Can be used for lysosomal uptake imaging in live cells. Also can be used for isolating hepatocytes due to its uptake via ASGPR receptor.

Application: Flow cytometry, fluorescence microscopy.

Properties and Photophysical Data: Suitable for multiplexing and can be combined with DAPI (Cat. No. 5748) counter-staining. Excitation and emission maxima (λ) are 663 and 684 nm, respectively.

Optical Data for tri-GalNAc-C5-AF647

λabs 663 nm
λem 684 nm
Cell Permeable Yes
Application Flow Cytometry, Fluorescence Microscopy

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Technical Data for tri-GalNAc-C5-AF647

M. Wt 2456.74
Formula C103H162N16O44S4
Storage Store at -20°C
Purity ≥90%
Smiles O=C(NC(COCC1=CN(N=N1)CCOCCOCCOCCO[C@H]2O[C@H]([C@@H](O)[C@@H](O)[C@@H]2NC(C)=O)CO)(COCC3=CN(N=N3)CCOCCOCCOCCO[C@@H]4O[C@@H]([C@H](O)[C@H](O)[C@H]4NC(C)=O)CO)COCC5=CN(N=N5)CCOCCOCCOCCO[C@H]6O[C@H]([C@@H](O)[C@@H](O)[C@@H]6NC(C)=O)CO)CCCCCNC(CCCCCC7(C(/C=C/C=C/C=C8C(C)(C9=C(N\8CCCS(=O)(O)=O)C=CC(S(=O)(O)=O)=C9)C)=[N+](C%10=C7C=C(C=C%10)S(=O)(O)=O)CCCS(=O)([O-])=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for tri-GalNAc-C5-AF647

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.57 10

Preparing Stock Solutions for tri-GalNAc-C5-AF647

The following data is based on the product molecular weight 2456.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 4.07 mL 20.35 mL 40.7 mL
0.5 mM 0.81 mL 4.07 mL 8.14 mL
1 mM 0.41 mL 2.04 mL 4.07 mL
5 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets for tri-GalNAc-C5-AF647

References for tri-GalNAc-C5-AF647

References are publications that support the biological activity of the product.

Sanhueza et al (2017) Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 139 3528 PMID: 28230359

If you know of a relevant reference for tri-GalNAc-C5-AF647, please let us know.

Keywords: tri-GalNAc-C5-AF647, tri-GalNAc-C5-AF647 supplier, triGalNAcC5AF647, ASGPR, asialoglycoprotein, receptor, ligand, hepatocytes, conjugation, LYTAC, lysosomal, targeting, chimera, alkylc5, degradation, degraders, Building, Blocks, in, vivo, Fluorescent, Lysosome, Probes, Receptor, 7901, Tocris Bioscience

Citations for tri-GalNAc-C5-AF647

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