tri-GalNAc biotin

Pricing Availability   Qty
Description: Biotinylated ASGPR ligand for LYTAC research and development
Purity: ≥90% (HPLC)
Literature (2)

Biological Activity for tri-GalNAc biotin

Tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).

Technical Data for tri-GalNAc biotin

M. Wt 1916.21
Formula C83H146N14O34S
Storage Store at -20°C
Purity ≥90% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for tri-GalNAc biotin

Solvent Max Conc. mg/mL Max Conc. mM
water 95.81 50

Preparing Stock Solutions for tri-GalNAc biotin

The following data is based on the product molecular weight 1916.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.04 mL 5.22 mL 10.44 mL
2.5 mM 0.21 mL 1.04 mL 2.09 mL
5 mM 0.1 mL 0.52 mL 1.04 mL
25 mM 0.02 mL 0.1 mL 0.21 mL

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Product Datasheets for tri-GalNAc biotin

Certificate of Analysis / Product Datasheet
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References for tri-GalNAc biotin

References are publications that support the biological activity of the product.

Zhou et al (2021) Development of triantennary N-acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent.Sci. 7 499 PMID: 33791431

If you know of a relevant reference for tri-GalNAc biotin, please let us know.

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Citations for tri-GalNAc biotin

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia