β-GalNAc-PEG4-Azide

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Description: Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
Chemical Name: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for β-GalNAc-PEG4-Azide

β-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, β-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. β-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Usage Guidelines for β-GalNAc-PEG4-Azide

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for β-GalNAc-PEG4-Azide

M. Wt 422.44
Formula C16H30N4O9
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 879004-92-9
PubChem ID 129115265
InChI Key DWQAFMMYPUXSPI-IBEHDNSVSA-N
Smiles [N-]=[N+]=NCCOCCOCCOCCO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for β-GalNAc-PEG4-Azide

References for β-GalNAc-PEG4-Azide

References are publications that support the biological activity of the product.

Sanhueza et al (2017) Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 139 3528 PMID: 28230359


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Keywords: beta-GalNAc-PEG4-Azide, beta-GalNAc-PEG4-Azide supplier, betaGalNAcPEG4Azide, ASGPR, asialoglycoprotein, receptor, ligand, hepatocytes, conjugation, LYTAC, lysosomal, targeting, chimera, PEG4, Azide, GalNAc, targeted, protein, degradation, degraders, TPD, building, blocks, Building, Blocks, Biochemicals, and, Molecular, Biology, 7780, Tocris Bioscience

Citations for β-GalNAc-PEG4-Azide

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