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Biological Activity for tri-GalNAc COOH
Tri-GalNAc COOH is a functionalized asialoglycoprotein receptor ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates an asialoglycoprotein receptor (ASGPR) ligand with PEG linker and carboxylic acid group reactive handle ready for conjugation to a target protein ligand. Upon binding to the ASGPR tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. Tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to liver hepatocytes.
Technical Data for tri-GalNAc COOH
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for tri-GalNAc COOH
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for tri-GalNAc COOH
The following data is based on the product molecular weight 1735.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||1.15 mL||5.76 mL||11.52 mL|
|2.5 mM||0.23 mL||1.15 mL||2.3 mL|
|5 mM||0.12 mL||0.58 mL||1.15 mL|
|25 mM||0.02 mL||0.12 mL||0.23 mL|
References for tri-GalNAc COOH
References are publications that support the biological activity of the product.
Zhou et al (2021) Development of triantennary N-Acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent. Sci. 7 499 PMID: 33791431
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Citations for tri-GalNAc COOH
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Literature in this Area
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Targeted Protein Degradation Research Product Guide
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Custom Degrader Services
- Ubiquitin-Proteasome System Proteins and Assays
- Assays for Protein Degradation
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia