tri-GalNAc COOH

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Description: Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
Chemical Name: 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
Purity: ≥90% (HPLC)
Literature (2)

Biological Activity for tri-GalNAc COOH

Tri-GalNAc COOH is a functionalized asialoglycoprotein receptor ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates an asialoglycoprotein receptor (ASGPR) ligand with PEG linker and carboxylic acid group reactive handle ready for conjugation to a target protein ligand. Upon binding to the ASGPR tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. Tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes.

Technical Data for tri-GalNAc COOH

M. Wt 1735.93
Formula C75H134N10O35
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1953146-81-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for tri-GalNAc COOH

Solvent Max Conc. mg/mL Max Conc. mM
water 86.8 50

Preparing Stock Solutions for tri-GalNAc COOH

The following data is based on the product molecular weight 1735.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.15 mL 5.76 mL 11.52 mL
2.5 mM 0.23 mL 1.15 mL 2.3 mL
5 mM 0.12 mL 0.58 mL 1.15 mL
25 mM 0.02 mL 0.12 mL 0.23 mL

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Product Datasheets for tri-GalNAc COOH

Certificate of Analysis / Product Datasheet
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References for tri-GalNAc COOH

References are publications that support the biological activity of the product.

Zhou et al (2021) Development of triantennary N-Acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent. Sci. 7 499 PMID: 33791431

If you know of a relevant reference for tri-GalNAc COOH, please let us know.

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Citations for tri-GalNAc COOH

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia