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Biological Activity for Calcipotriol
Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.
Technical Data for Calcipotriol
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Calcipotriol
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Calcipotriol
The following data is based on the product molecular weight 412.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.42 mL||12.12 mL||24.24 mL|
|5 mM||0.48 mL||2.42 mL||4.85 mL|
|10 mM||0.24 mL||1.21 mL||2.42 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for Calcipotriol
References are publications that support the biological activity of the product.
Binderu (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240 PMID: 8396769
Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829 PMID: 9113104
Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447 PMID: 17351397
Lovato et al (2016) Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J.Dermatol.Sci. 81 153 PMID: 26794805
Cunningham et al (2017) Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J.Clin.Invest. 127 106 PMID: 27869649
If you know of a relevant reference for Calcipotriol, please let us know.
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Keywords: Calcipotriol, Calcipotriol supplier, Vitamin, D3, D, Receptors, VDR-like, MC903, analogues, MC, 903, 2700, Tocris Bioscience
3 Citations for Calcipotriol
Citations are publications that use Tocris products. Selected citations for Calcipotriol include:
Malhotra et al (2018) RORα-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol 3 PMID: 29500225
Wei et al (2018) Vitamin D switches BAF complexes to protect β cells. Cell 173 1135 PMID: 29754817
Landheer et al (2015) TSLP is differentially regulated by vitamin D3 and cytokines in human skin. Dev.Biol. 3 32 PMID: 25866638
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Reviews for Calcipotriol
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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