Calcipotriol

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Cat.No. 2700 - Calcipotriol | C27H40O3 | CAS No. 112965-21-6
Description: Vitamin D3 analog
Alternative Names: MC 903
Chemical Name: (1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Technical Data

M. Wt 412.6
Formula C27H40O3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 112965-21-6
PubChem ID 5288783
InChI Key LWQQLNNNIPYSNX-UROSTWAQSA-N
Smiles [H][C@@]12[C@]([C@]([C@@H](/C=C/[C@@H](O)C4CC4)C)([H])CC2)(C)CCC/C1=C\C=C3/C([C@@H](O)C[C@H](O)C3)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.26 100
ethanol 41.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 412.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Binderu (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240 PMID: 8396769

Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829 PMID: 9113104

Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447 PMID: 17351397


If you know of a relevant reference for Calcipotriol, please let us know.

View Related Products by Target

Keywords: Vitamin D3 D Receptors VDR-like MC903 MC 903 Vitamin D Receptors

1 Citation for Calcipotriol

Citations are publications that use Tocris products. Selected citations for Calcipotriol include:

Landheer et al (2015) TSLP is differentially regulated by vitamin D3 and cytokines in human skin. Dev Biol 3 32 PMID: 25866638


Do you know of a great paper that uses Calcipotriol from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

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Nuclear Receptors Product Listing

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Pathways for Calcipotriol

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