Calcitriol

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Cat.No. 2551 - Calcitriol | C27H44O3 | CAS No. 32222-06-3
Description: Vitamin D receptor (VDR) agonist
Alternative Names: 1,25-Dihydroxyvitamin D3
Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Technical Data

M. Wt 416.64
Formula C27H44O3
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 32222-06-3
PubChem ID 5280453
InChI Key GMRQFYUYWCNGIN-NKMMMXOESA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(C)O)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO and in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 416.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12 mL 24 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865 PMID: 11004217

Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373 PMID: 15026558

Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589 PMID: 16873882


If you know of a relevant reference for Calcitriol, please let us know.

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Keywords: Calcitriol, supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3, 1,25-Dihydroxyvitamin, D3, Vitamin, D, Receptors, Tocris Bioscience

2 Citations for Calcitriol

Citations are publications that use Tocris products. Selected citations for Calcitriol include:

Pal et al (2010) Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification. J Neurosci 210 88 PMID: 20004897

Sharma et al (2015) A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Atherosclerosis 10 2346 PMID: 25629933


Do you know of a great paper that uses Calcitriol from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

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  • Epigenetics in Cancer
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Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

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  • Estrogen Receptors
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  • Retinoid X Receptors
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Pathways for Calcitriol

Protocols

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