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Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in DMSO and in ethanol|
References are publications that support the biological activity of the product.
Canalejo et al (2000) The in vitro effect of calci. on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865 PMID: 11004217
Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373 PMID: 15026558
Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589 PMID: 16873882
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Keywords: Calcitriol, Calcitriol supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3, 1,25-Dihydroxyvitamin, D3, 2551, Tocris Bioscience
2 Citations for Calcitriol
Citations are publications that use Tocris products. Selected citations for Calcitriol include:
Pal et al (2010) Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification. J Neurosci 210 88 PMID: 20004897
Sharma et al (2015) A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Atherosclerosis 10 2346 PMID: 25629933
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