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Submit ReviewCalcitriol
Description: Vitamin D receptor (VDR) agonist
Alternative Names: 1,25-Dihydroxyvitamin D3
Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
Purity: ≥99% (HPLC)
Biological Activity for Calcitriol
Calcitriol is an active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
Technical Data for Calcitriol
| M. Wt | 416.64 |
| Formula | C27H44O3 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 32222-06-3 |
| PubChem ID | 5280453 |
| InChI Key | GMRQFYUYWCNGIN-NKMMMXOESA-N |
| Smiles | C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(C)O)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Calcitriol
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.33 | 20 | |
| ethanol | 2.08 | 5 |
Preparing Stock Solutions for Calcitriol
The following data is based on the product molecular weight 416.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12 mL | 60 mL | 120.01 mL |
| 1 mM | 2.4 mL | 12 mL | 24 mL |
| 2 mM | 1.2 mL | 6 mL | 12 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
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Product Datasheets for Calcitriol
References for Calcitriol
References are publications that support the biological activity of the product.
Canalejo et al (2000) The in vitro effect of calci. on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865 PMID: 11004217
Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373 PMID: 15026558
Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589 PMID: 16873882
If you know of a relevant reference for Calcitriol, please let us know.
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Keywords: Calcitriol, Calcitriol supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3, 1,25-Dihydroxyvitamin, D3, 2551, Tocris Bioscience
2 Citations for Calcitriol
Citations are publications that use Tocris products. Selected citations for Calcitriol include:
Sharma et al (2015) A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Atherosclerosis 10 2346 PMID: 25629933
Pal et al (2010) Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification. J Neurosci 210 88 PMID: 20004897
Do you know of a great paper that uses Calcitriol from Tocris? Please let us know.
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