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The polycystin transient receptor potential (TRPP) channels are a subfamily of TRP channels that, when mutated, can lead to polycystic kidney disease. TRPP channels are divided into two distinct groups, polycystic kidney disease 1-like and polycystic kidney disease 2-like.
|Cat No||Product Name / Activity|
|Na+ channel blocker; inhibits TRPP3 channel|
|NCX inhibitor; inhibits TRPP3 channel activity|
|Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)|
|Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels|
The polycystin transient receptor potential (TRPP) channels are a subfamily of TRP channels that, when mutated, can lead to polycystic kidney disease. The TRPP channels are divided into two structurally distinct groups, polycystic kidney disease 1-like (PKD1-like) and polycystic kidney disease 2-like (PKD2-like). Members of the PKD1-like group in mammals include PKD1 (reclassified as TRPP1), PDKREJ, PKD1L1, PKD1L2 and PKD1L3. The PKD2-like members include PKD2; PKD2L1; and PKD2L2, which have renamed TRPP2; TRPP3; and TRPP5 respectively.
TRPP1 contains 11 putative transmembrane domains and an extremely large and complex extracellular N-terminal domain. It has also been suggested that TRPP1 and TRPP2 can physically couple to act as a signaling complex, yet TRPP1 appears to be incapable of producing currents so may not form a functional channel. In contrast, TRPP2 is suggested to be important for cilia movement, development of the heart, skeletal muscle and kidney. TRPP3 plays a role in retinal development, whilst there is limited functional data for TRPP4 and -5.
External sources of pharmacological information for TRPP :
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|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
|Polycystic kidney disease 1||Human||PKD1||NM_000296||P98161|
|Polycystic kidney disease 2||Human||PKD2||NM_000297||Q13563|
|Polycystic kidney disease 2-like 1||Human||PKD2L1||NM_016112||Q9P0L9|
|Polycystic kidney disease 2-like 2||Human||PKD2L2||NM_014386||Q9NZM6|