TRPP

The polycystin transient receptor potential (TRPP) channels are a subfamily of TRP channels that, when mutated, can lead to polycystic kidney disease. TRPP channels are divided into two distinct groups, polycystic kidney disease 1-like and polycystic kidney disease 2-like.

Products
Background
Literature
Gene Data

Blockers

Cat No Product Name / Activity
0890 Amiloride hydrochloride
Na+ channel blocker; inhibits TRPP3 channel
3380 Benzamil
NCX inhibitor; inhibits TRPP3 channel activity
3378 EIPA
Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)
3379 Phenamil
Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels

The polycystin transient receptor potential (TRPP) channels are a subfamily of TRP channels that, when mutated, can lead to polycystic kidney disease. The TRPP channels are divided into two structurally distinct groups, polycystic kidney disease 1-like (PKD1-like) and polycystic kidney disease 2-like (PKD2-like). Members of the PKD1-like group in mammals include PKD1 (reclassified as TRPP1), PDKREJ, PKD1L1, PKD1L2 and PKD1L3. The PKD2-like members include PKD2; PKD2L1; and PKD2L2, which have renamed TRPP2; TRPP3; and TRPP5 respectively.

TRPP1 contains 11 putative transmembrane domains and an extremely large and complex extracellular N-terminal domain. It has also been suggested that TRPP1 and TRPP2 can physically couple to act as a signaling complex, yet TRPP1 appears to be incapable of producing currents so may not form a functional channel. In contrast, TRPP2 is suggested to be important for cilia movement, development of the heart, skeletal muscle and kidney. TRPP3 plays a role in retinal development, whilst there is limited functional data for TRPP4 and -5.

External sources of pharmacological information for TRPP :

Literature for TRPP

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TRPP Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Polycystic kidney disease 1 Human PKD1 NM_000296 P98161
Mouse Pkd1 NM_013630 NP_038658
Rat Pkd1 NM_001257352 NP_001244281
Polycystic kidney disease 2 Human PKD2 NM_000297 Q13563
Mouse Pkd2 NM_008861 NP_032887
Rat - - -
Polycystic kidney disease 2-like 1 Human PKD2L1 NM_016112 Q9P0L9
Mouse Pkd2l1 NM_181422 NP_852087
Rat Pkd2l1 NM_001106352 NP_001099822
Polycystic kidney disease 2-like 2 Human PKD2L2 NM_014386 Q9NZM6
Mouse Pkd2l2 NM_016927 NP_058623
Rat Pkd2l2 NM_001106156 NP_001099626