EIPA

Pricing Availability Delivery Time Qty
Cat.No. 3378 - EIPA | C11H18ClN7O | CAS No. 1154-25-2
Description: Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)
Alternative Names: Ethylisopropyl amiloride
Chemical Name: 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

TRPP3 channel inhibitor (IC50 = 10.5 μM). Inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride (Cat. No. 0890).

Compound Libraries

EIPA is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 299.76
Formula C11H18ClN7O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1154-25-2
PubChem ID 1795
InChI Key QDERNBXNXJCIQK-UHFFFAOYSA-N
Smiles ClC1=C(N(C(C)C)CC)N=C(N)C(C(NC(N)=N)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 14.99 50
DMSO 29.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 299.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.36 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601

Horinouchi et al (2008) Functional role of Na+/H+ exchanger in Ca2+ influx mediated via human endothelin type A receptor stably expressed in Chinese hamster ovary cells. J.Pharm.Sci. 107 456 PMID: 18678984


If you know of a relevant reference for EIPA, please let us know.

View Related Products by Product Action

View all TRPP Blockers

Keywords: EIPA, supplier, sodium, hydrogen, exchangers, NHE-1, NHE, blockers, inhibitors, inhibits, TRPP3, antagonists, Amiloride, ethylisopropyl, amiloride, Ethylisopropyl, amiloride, Na+/H+, Exchanger, TRPP, TRPP, Tocris Bioscience

Citations for EIPA

Citations are publications that use Tocris products.

Currently there are no citations for EIPA. Do you know of a great paper that uses EIPA from Tocris? If so please let us know.

EIPA Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used EIPA?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells