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TRPP3 channel inhibitor (IC50 = 10.5 μM). Inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride (Cat. No. 0890).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 299.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.34 mL||16.68 mL||33.36 mL|
|5 mM||0.67 mL||3.34 mL||6.67 mL|
|10 mM||0.33 mL||1.67 mL||3.34 mL|
|50 mM||0.07 mL||0.33 mL||0.67 mL|
References are publications that support the biological activity of the product.
Dai et al (2007) Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601
Horinouchi et al (2008) Functional role of Na+/H+ exchanger in Ca2+ influx mediated via human endothelin type A receptor stably expressed in Chinese hamster ovary cells. J.Pharm.Sci. 107 456 PMID: 18678984
If you know of a relevant reference for EIPA, please let us know.
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Keywords: EIPA, EIPA supplier, sodium, hydrogen, exchangers, NHE-1, NHE, blockers, inhibitors, inhibits, TRPP3, antagonists, Amiloride, ethylisopropyl, amiloride, Ethylisopropyl, Na+/H+, Exchanger, TRPP, 3378, Tocris Bioscience
2 Citations for EIPA
Citations are publications that use Tocris products. Selected citations for EIPA include:
Knudsen et al (2019) Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production. Cell Metab 29 430 PMID: 30415925
Neubert et al (2020) NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages. PloS Biol 18 PMID: 32569301
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