Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels
Chemical Name: 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
Purity: ≥99% (HPLC)

Biological Activity for Phenamil

Phenamil is a TRPP3 channel inhibitor (IC50 = 0.14 μM). Also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Derivative of amiloride (Cat. No. 0890).

Compound Libraries for Phenamil

Phenamil is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Phenamil

M. Wt 401.83
Formula C12H12ClN7O.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1161-94-0
PubChem ID 9604979
Smiles NC1=C(Cl)N=C(C(NC(NC2=CC=CC=C2)=N)=O)C(N)=N1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Phenamil

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.18 100

Preparing Stock Solutions for Phenamil

The following data is based on the product molecular weight 401.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Phenamil

References are publications that support the biological activity of the product.

Barbry et al (1989) Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. Biochemistry. 28 3744 PMID: 2546581

Dai et al (2007) Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601

If you know of a relevant reference for Phenamil, please let us know.

View Related Products by Product Action

View all TRPP Channel Blockers

Keywords: Phenamil, Phenamil supplier, TRPP3, TRP, antagonists, sodium, channels, blocker, amiloride, Na, epithelial, Epithelial, Sodium, Channels, TRPP, 3379, Tocris Bioscience

Citations for Phenamil

Citations are publications that use Tocris products.

Currently there are no citations for Phenamil. Do you know of a great paper that uses Phenamil from Tocris? Please let us know.

Reviews for Phenamil

There are currently no reviews for this product. Be the first to review Phenamil and earn rewards!

Have you used Phenamil?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review