Phenamil

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Cat.No. 3379 - Phenamil | C12H12ClN7O.CH3SO3H | CAS No. 1161-94-0
Description: Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels
Chemical Name: 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

TRPP3 channel inhibitor (IC50 = 0.14 μM). Also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Derivative of amiloride (Cat. No. 0890).

Technical Data

M. Wt 401.83
Formula C12H12ClN7O.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1161-94-0
PubChem ID 9604979
InChI Key MHPIZTURFVSLTJ-UHFFFAOYSA-N
Smiles NC1=C(Cl)N=C(C(NC(NC2=CC=CC=C2)=N)=O)C(N)=N1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 401.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References

References are publications that support the biological activity of the product.

Barbry et al (1989) Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. Biochemistry. 28 3744 PMID: 2546581

Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601


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Keywords: Phenamil, Phenamil supplier, TRPP3, TRP, antagonists, sodium, channels, blocker, amiloride, Na, epithelial, Epithelial, Sodium, Channels, TRPP, 3379, Tocris Bioscience

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