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TRPP3 channel inhibitor (IC50 = 0.14 μM). Also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Derivative of amiloride (Cat. No. 0890).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 401.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.49 mL||12.44 mL||24.89 mL|
|5 mM||0.5 mL||2.49 mL||4.98 mL|
|10 mM||0.25 mL||1.24 mL||2.49 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the biological activity of the product.
Barbry et al (1989) Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. Biochemistry. 28 3744 PMID: 2546581
Dai et al (2007) Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601
If you know of a relevant reference for Phenamil, please let us know.
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Keywords: Phenamil, Phenamil supplier, TRPP3, TRP, antagonists, sodium, channels, blocker, amiloride, Na, epithelial, Epithelial, Sodium, Channels, TRPP, 3379, Tocris Bioscience
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