Translocator Protein

The translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor or PBR, is an 18 KDa protein that is ubiquitously expressed and localized to the outer mitochondrial membrane in eukaryotes, but its function remains obscure.

Products
Background
Literature
Gene Data

Ligands

Cat No Product Name / Activity
5281 AC 5216
Selective TSPO ligand
3113 Etifoxine hydrochloride
Ligand of the translocator protein (TSPO); also GABAA receptor potentiator
0670 PK 11195
Antagonist at peripheral benzodiazepine receptors

Other

Cat No Product Name / Activity
0658 FGIN-1-27
Potent, specific ligand for mitochondrial DBI receptor
0659 FGIN-1-43
Potent, specific ligand for mitochondrial DBI receptor

Related Targets

    The translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor or PBR, is an 18 KDa protein that is ubiquitously expressed and localized to the outer mitochondrial membrane in eukaryotes. It was first identified in 1977 as a secondary binding site for benzodiazepines, but its function remains obscure. Crystal and NMR structures have revealed that the protein has some characteristics of both a transporter and a G-protein coupled receptor. Cholesterol, porphyrins and the naturally occurring polypeptide diazepam binding inhibitor (DBI) have been proposed as endogenous ligands for the protein.

    TSPO has a role in the stress response, being induced by a diverse range of environmental stress conditions across many species, including inflammation and cancer in animals. Expression of TSPO is upregulated in the mitochondria of microglial cells when activated in response to inflammatory stimuli, so TSPO ligands have been proposed as imaging agents for neuroinflammatory conditions, such as Parkinson's and Alzheimer's diseases, as well as brain tumors. The protein also appears to be involved in steroidogenesis, as TSPO ligands promote steroid formation in adrenal, gonad, brain, placenta and liver tissues. Studies have additionally suggested a role for TSPO in the formation and function of adipocytes, so it is a potential target for therapy in type 2 diabetes and obesity.

    External sources of pharmacological information for Translocator Protein :

      Literature for Translocator Protein

      Cancer

      Cancer Research Product Guide

      A collection of over 750 products for cancer research, the guide includes research tools for the study of:

      • Cancer Metabolism
      • Epigenetics in Cancer
      • Receptor Signaling
      • Cell Cycle and DNA Damage Repair
      • Angiogenesis
      • Invasion and Metastasis
      Neurodegeneration

      Neurodegeneration Product Guide

      A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

      • Alzheimer's disease
      • Parkinson's disease
      • Huntington's disease

      Translocator Protein Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      Translocator Protein (TSPO) Human TSPO NM_007311 B1AH88
      Mouse Tspo NM_009775 P50637
      Rat Tspo NM_012515 P16257