Etifoxine hydrochloride

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Cat.No. 3113 - Etifoxine hydrochloride | C17H17ClN2O.HCl | CAS No. 56776-32-0
Description: Ligand of the translocator protein (TSPO); also GABAA receptor potentiator
Chemical Name: 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2 or β3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.

Technical Data

M. Wt 337.24
Formula C17H17ClN2O.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 56776-32-0
PubChem ID 171544
InChI Key SCBJXEBIMVRTJE-UHFFFAOYSA-N
Smiles CCNC2=NC1=CC=C(Cl)C=C1C(C3=CC=CC=C3)(C)O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.72 100
water 1.69 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 337.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.83 mL 29.65 mL
5 mM 0.59 mL 2.97 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References

References are publications that support the biological activity of the product.

Hamon et al (2003) The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit. Neuropharmacology 45 293 PMID: 12871647

Girard et al (2008) Etifoxine improves peripheral nerve regeneration and functional recovery. Proc.Natl.Acad.Sci. 105 20505


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Citations for Etifoxine hydrochloride

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