Potentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2 or β3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||1.69||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 337.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.97 mL||14.83 mL||29.65 mL|
|5 mM||0.59 mL||2.97 mL||5.93 mL|
|10 mM||0.3 mL||1.48 mL||2.97 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References are publications that support the biological activity of the product.
Hamon et al (2003) The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit. Neuropharmacology 45 293 PMID: 12871647
Girard et al (2008) Etifoxine improves peripheral nerve regeneration and functional recovery. Proc.Natl.Acad.Sci. 105 20505
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