AC 5216

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Cat.No. 5281 - AC 5216 | C23H23N5O2 | CAS No. 226954-04-7
Description: Selective TSPO ligand
Alternative Names: XBD173
Chemical Name: N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.

Compound Libraries

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Technical Data

M. Wt 401.46
Formula C23H23N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 226954-04-7
PubChem ID 6433109
InChI Key NBMBIEOUVBHEBM-UHFFFAOYSA-N
Smiles O=C(N1C)N(CC(N(CC)CC2=CC=CC=C2)=O)C3=C1C=NC(C4=CC=CC=C4)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.15 100
ethanol 4.01 10 with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 401.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.45 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References

References are publications that support the biological activity of the product.

Kita et al (2004) Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br.J.Pharmacol. 142 1059 PMID: 15249420

Qiu et al (2013) Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry 45 40 PMID: 23624119


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Keywords: AC 5216, AC 5216 supplier, AC5216, anxiolytic, anti-anxiety, antidepressant, mitochondrial, benzodiazepine, BZD, ligands, PBR, TSPO, GABAA, XBD173, Translocator, Protein, 5281, Tocris Bioscience

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