AC 5216

Pricing Availability   Qty
Description: Selective TSPO ligand
Alternative Names: XBD173
Chemical Name: N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
Purity: ≥98% (HPLC)

Biological Activity for AC 5216

AC 5216 is a ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.

Compound Libraries for AC 5216

AC 5216 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 5216

M. Wt 401.46
Formula C23H23N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 226954-04-7
PubChem ID 6433109
Smiles O=C(N1C)N(CC(N(CC)CC2=CC=CC=C2)=O)C3=C1C=NC(C4=CC=CC=C4)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AC 5216

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.15 100

Preparing Stock Solutions for AC 5216

The following data is based on the product molecular weight 401.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.45 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for AC 5216

Certificate of Analysis / Product Datasheet
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References for AC 5216

References are publications that support the biological activity of the product.

Kita et al (2004) Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br.J.Pharmacol. 142 1059 PMID: 15249420

Qiu et al (2013) Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry 45 40 PMID: 23624119

If you know of a relevant reference for AC 5216, please let us know.

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Keywords: AC 5216, AC 5216 supplier, AC5216, anxiolytic, anti-anxiety, antidepressant, depression, mitochondrial, benzodiazepine, BZD, ligands, PBR, TSPO, GABAA, XBD173, Translocator, Protein, 5281, Tocris Bioscience

Citations for AC 5216

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