Telomerase

Telomerase is a ribonucleoprotein composed of an internal telomerase RNA template (TERC) and the enzyme, telomerase reverse transcriptase (TERT). Telomerase adds repeat sequences of DNA (TTAGGG) to the end of chromosomes - multiple repeats of this are a 'telomere'.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
2981 BIBR 1532
Selective telomerase inhibitor
5312 BRACO 19 trihydrochloride
Telomerase inhibitor
2483 Costunolide
Inhibitor of human telomerase activity
5311 RHPS 4 methosulfate
Telomerase inhibitor
4253 TMPyP4 tosylate
Inhibitor of human telomerase

Other

Cat No Product Name / Activity
5441 5-TAMRA SE
Fluorescent probe for DNA and RNA; also shown to stain telomeres

Telomerase is a ribonucleoprotein composed of an internal telomerase RNA template (TERC) and the enzyme, telomerase reverse transcriptase (TERT). Telomerase adds small repeat sequences of DNA (TTAGGG) to the end of chromosomes - multiple repeats of this hexanucleotide sequence over a 5kb span are known as a telomere.

During normal cellular replication, telomeres are eroded and thus protect the coding sequences of the DNA. The erosion of telomeric sequences is thought to form the basis of the cellular clock which eventually signals for the cell to exit the cell cycle and undergo senescence. Expression of telomerase is low in most normal cells although it is thought to be active in embryonic cells and some rapidly dividing cells of the immune system. Overexpression of telomerase is key component of the transformation process in many malignant cancer cells.

Literature for Telomerase

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Telomerase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TERT Human TERT NM_198255 O14746
Mouse Tert NM_009354 O70372
Rat Tert NM_053423 Q673L6
TERC Human TERC NR_001566 602322
Mouse Terc NR_001579 -
Rat Terc NR_001567 -
DCK1 Human DCK1 NM_001363 O60832
Mouse Dck1 NM_001030307 Q9ESX5
Rat Dck1 NM_133419 P40615