Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1363.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||1.47 mL||7.33 mL||14.67 mL|
|2.5 mM||0.29 mL||1.47 mL||2.93 mL|
|5 mM||0.15 mL||0.73 mL||1.47 mL|
|25 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the biological activity of the product.
Rha et al (2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 6 987 PMID: 10741725
Shammas et al (2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2 825 PMID: 14555701
Wheelhouse et al (1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc. 120 3261
Shi et al (2001) Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem. 474 4509
If you know of a relevant reference for TMPyP4 tosylate, please let us know.
View Related Products by Product Action
Keywords: TMPyP4 tosylate, TMPyP4 tosylate supplier, TMPyP4, telomerase, inhibitors, inhibits, g, tetrads, quadruplex, DNA, telomeres, Telomerase, 4253, Tocris Bioscience
Citations for TMPyP4 tosylate
Citations are publications that use Tocris products.
Currently there are no citations for TMPyP4 tosylate. Do you know of a great paper that uses TMPyP4 tosylate from Tocris? Please let us know.
Reviews for TMPyP4 tosylate
There are currently no reviews for this product. Be the first to review TMPyP4 tosylate and earn rewards!
Have you used TMPyP4 tosylate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.