TMPyP4 tosylate

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Cat.No. 4253 - TMPyP4 tosylate | C72H66N8O12S4 | CAS No. 36951-72-1
Description: Inhibitor of human telomerase
Chemical Name: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.

Technical Data

M. Wt 1363.6
Formula C72H66N8O12S4
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 36951-72-1
PubChem ID 11979833
InChI Key AKZFRMNXBLFDNN-UHFFFAOYSA-K
Smiles C[N+](C=C9)=CC=C9/C(C2=CC=C(/C(C8=CC=[N+](C)C=C8)=C3/C=CC4=N3)N2)=C1N=C(/C(C7=CC=[N+](C)C=C7)=C(N6)/C=C\C6=C4/C5=CC=[N+](C)C=C5)C=C\1.CC%10=CC=C(S(=O)([O-])=O)C=C%10.CC%11=CC=C(S(=O)([O-])=O)C=C%11.CC%12=CC=C(S(=O)([O-])=O)C=C%12.CC%13=CC=C(S(=O)([O-])=O)C=C%13

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 68.18 50

Preparing Stock Solutions

The following data is based on the product molecular weight 1363.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.73 mL 3.67 mL 7.33 mL
5 mM 0.15 mL 0.73 mL 1.47 mL
10 mM 0.07 mL 0.37 mL 0.73 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rha et al (2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 6 987 PMID: 10741725

Shammas et al (2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2 825 PMID: 14555701

Wheelhouse et al (1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc. 120 3261 PMID:

Shi et al (2001) Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem. 474 4509 PMID:


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Keywords: TMPyP4 tosylate, supplier, TMPyP4, telomerase, inhibitors, inhibits, g, tetrads, quadruplex, DNA, telomeres, Telomerase, Telomerase, Tocris Bioscience

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Literature in this Area

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Cancer

Cancer Research Product Guide

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