TMPyP4 tosylate

Pricing Availability   Qty
Description: Inhibitor of human telomerase
Chemical Name: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)
Purity: ≥95% (HPLC)
Citations (1)

Biological Activity for TMPyP4 tosylate

TMPyP4 tosylate is a cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.

Technical Data for TMPyP4 tosylate

M. Wt 1363.6
Formula C72H66N8O12S4
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 36951-72-1
PubChem ID 11979833
Smiles CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.C[N+]1=CC=C(C=C1)C1=C2\C=CC(=N2)\C(=C2/N\C(\C=C2)=C(/C2=N/C(/C=C2)=C(\C2=CC=C\1N2)C1=CC=[N+](C)C=C1)C1=CC=[N+](C)C=C1)\C1=CC=[N+](C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TMPyP4 tosylate

Solvent Max Conc. mg/mL Max Conc. mM
water 68.18 50

Preparing Stock Solutions for TMPyP4 tosylate

The following data is based on the product molecular weight 1363.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 1.47 mL 7.33 mL 14.67 mL
2.5 mM 0.29 mL 1.47 mL 2.93 mL
5 mM 0.15 mL 0.73 mL 1.47 mL
25 mM 0.03 mL 0.15 mL 0.29 mL

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Product Datasheets for TMPyP4 tosylate

Certificate of Analysis / Product Datasheet
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References for TMPyP4 tosylate

References are publications that support the biological activity of the product.

Rha et al (2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 6 987 PMID: 10741725

Shammas et al (2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2 825 PMID: 14555701

Wheelhouse et al (1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc. 120 3261

Shi et al (2001) Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem. 474 4509

If you know of a relevant reference for TMPyP4 tosylate, please let us know.

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Keywords: TMPyP4 tosylate, TMPyP4 tosylate supplier, TMPyP4, telomerase, inhibitors, inhibits, g, tetrads, quadruplex, DNA, telomeres, Telomerase, 4253, Tocris Bioscience

1 Citation for TMPyP4 tosylate

Citations are publications that use Tocris products. Selected citations for TMPyP4 tosylate include:

Ole et al (2019) Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts. Hum Mol Genet 28 3232-3243 PMID: 31261377

Do you know of a great paper that uses TMPyP4 tosylate from Tocris? Please let us know.

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