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Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1363.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||1.47 mL||7.33 mL||14.67 mL|
|2.5 mM||0.29 mL||1.47 mL||2.93 mL|
|5 mM||0.15 mL||0.73 mL||1.47 mL|
|25 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the biological activity of the product.
Rha et al (2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 6 987 PMID: 10741725
Shammas et al (2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2 825 PMID: 14555701
Wheelhouse et al (1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc. 120 3261
Shi et al (2001) Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem. 474 4509
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