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RHPS 4 methosulfate is a telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. Sensitizes radiation resistant glioblastoma cell lines to radiation.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||4.58||10 with gentle warming|
The following data is based on the product molecular weight 458.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.91 mL||54.53 mL||109.06 mL|
|1 mM||2.18 mL||10.91 mL||21.81 mL|
|2 mM||1.09 mL||5.45 mL||10.91 mL|
|10 mM||0.22 mL||1.09 mL||2.18 mL|
References are publications that support the biological activity of the product.
Lagah et al (2014) RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One 9 e86187 PMID: 24454961
Salvati et al (2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J.Clin.Invest. 117 3236 PMID: 17932567
Phatak et al (2007) Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br.J.Cancer 96 1223 PMID: 17406367
Berardinelli et al (2015) The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells. DNA Repair (Amst.) 25 104 PMID: 25467559
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