Na+/K+ ATPase

The Na+/K+ ATPase is a membrane protein that is composed of two subunits - α and β. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.

Products
Background
Literature
Gene Data

Modulators

Cat No Product Name / Activity
5315 Rostafuroxin
Na+/K+ ATPase modulator; antihypertensive agent

Inhibitors

Cat No Product Name / Activity
4583 Digoxin
Na+/K+ ATPase inhibitor
4740 Lithium carbonate
Mood stabilizer; inhibits Na+/K+ ATPase pump activity
1076 Ouabain
Na+/K+ ATPase inhibitor

Related Targets

    The Na+/K+ ATPase is a membrane protein that is composed of two subunits - α and β. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions, and is the driving force for membrane excitability.

    The Na+ gradient set by the Na+/K+ ATPase is functionally coupled to the Na+/Ca2+ exchanger (NCX) and therefore the Na+/K+ ATPase can also indirectly influence intracellular calcium concentration. For example, inhibition of the Na+/K+ ATPase in vascular smooth muscle cells and cardiomyocytes leads to the reversal of the Na+/Ca2+ exchanger and results in an increased force of contraction in the heart muscle and in arteries. This effect is induced therapeutically in the treatment of heart failure.

    The Na+/K+ ATPase is also involved in additional cellular processes including excitability of nerves, and the transport of glucose and amino acids across the cell membrane. More recently, evidence has emerged of a second role for the Na+/K+ ATPase as a signaling mediator: the extracellular loops of the catalytic α subunit act as a receptor for cardiac glycosides. Upon ligand binding to the extracellular loops, the Na+/K+ ATPase interacts with neighboring proteins and influences cellular functions including protein synthesis.

    Literature for Na+/K+ ATPase

    Cardiovascular

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    • Heart Failure
    Cardiovascular

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    Na+/K+ ATPase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    ATP1A1 Human ATP1A1 NM_000701 P05023
    Mouse Atp1a1 NM_144900 Q8VDN2
    Rat Atp1a1 NM_012504 P06685
    ATP1A2 Human ATP1A2 NM_000702 P50993
    Mouse Atp1a2 NM_178405 Q6PIE5
    Rat Atp1a2 NM_012505 P06686
    ATP1A3 Human ATP1A3 NM_152296 P13637
    Mouse Atp1a3 NM_144921 Q6PIC6
    Rat Atp1a3 NM_012506 P06687
    ATP1A4 Human ATP1A4 NM_144699 Q13733
    Mouse Atp1a4 NM_013734 Q9WV27
    Rat Atp1a4 NM_001271030 Q64541
    ATP1B1 Human ATP1B1 NM_001677 P05026
    Mouse Atp1b1 NM_009721 P14094
    Rat Atp1b1 NM_013113 P07340
    ATP1B2 Human ATP1B2 NM_001678 P14415
    Mouse Atp1b2 NM_013415 P14231
    Rat Atp1b2 NM_012507 P13638
    ATP1B3 Human ATP1B3 NM_001679 P54709
    Mouse Atp1b3 NM_007502 P97370
    Rat Atp1b3 NM_012913 Q63377
    ATP1B4 Human ATP1B4 NM_001142447 Q9UN42
    Mouse Atp1b4 NM_133690 Q99ME6
    Rat Atp1b4 NM_053381 Q9R193