Na+/K+ ATPase

The Na+/K+ ATPase is a membrane protein that is composed of two subunits - α and β. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.

Products
Background
Literature (2)
Gene Data

Modulators

Cat. No. Product Name / Activity
5315 Rostafuroxin
Na+/K+ ATPase modulator; antihypertensive agent

Inhibitors

Cat. No. Product Name / Activity
4583 Digoxin
Na+/K+ ATPase inhibitor
4740 Lithium carbonate
Mood stabilizer; inhibits Na+/K+ ATPase pump activity
1076 Ouabain
Na+/K+ ATPase inhibitor

Related Targets

    The Na+/K+ ATPase is a membrane protein that is composed of two subunits - α and β. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions, and is the driving force for membrane excitability.

    The Na+ gradient set by the Na+/K+ ATPase is functionally coupled to the Na+/Ca2+ exchanger (NCX) and therefore the Na+/K+ ATPase can also indirectly influence intracellular calcium concentration. For example, inhibition of the Na+/K+ ATPase in vascular smooth muscle cells and cardiomyocytes leads to the reversal of the Na+/Ca2+ exchanger and results in an increased force of contraction in the heart muscle and in arteries. This effect is induced therapeutically in the treatment of heart failure.

    The Na+/K+ ATPase is also involved in additional cellular processes including excitability of nerves, and the transport of glucose and amino acids across the cell membrane. More recently, evidence has emerged of a second role for the Na+/K+ ATPase as a signaling mediator: the extracellular loops of the catalytic α subunit act as a receptor for cardiac glycosides. Upon ligand binding to the extracellular loops, the Na+/K+ ATPase interacts with neighboring proteins and influences cellular functions including protein synthesis.

    External sources of pharmacological information for Na+/K+ ATPase :

      Literature for Na+/K+ ATPase

      Tocris offers the following scientific literature for Na+/K+ ATPase to showcase our products. We invite you to request* or download your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.


      Cardiovascular

      Cardiovascular Research Product Guide

      A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

      • Hypertension
      • Thrombosis and Hemostasis
      • Atherosclerosis
      • Myocardial Infarction
      • Ischemia/Reperfusion Injury
      • Arrhythmias
      • Heart Failure
      Cardiovascular

      Cardiovascular Poster

      Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

      Na+/K+ ATPase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      ATP1A1 Human ATP1A1 NM_000701 P05023
      Mouse Atp1a1 NM_144900 Q8VDN2
      Rat Atp1a1 NM_012504 P06685
      ATP1A2 Human ATP1A2 NM_000702 P50993
      Mouse Atp1a2 NM_178405 Q6PIE5
      Rat Atp1a2 NM_012505 P06686
      ATP1A3 Human ATP1A3 NM_152296 P13637
      Mouse Atp1a3 NM_144921 Q6PIC6
      Rat Atp1a3 NM_012506 P06687
      ATP1A4 Human ATP1A4 NM_144699 Q13733
      Mouse Atp1a4 NM_013734 Q9WV27
      Rat Atp1a4 NM_001271030 Q64541
      ATP1B1 Human ATP1B1 NM_001677 P05026
      Mouse Atp1b1 NM_009721 P14094
      Rat Atp1b1 NM_013113 P07340
      ATP1B2 Human ATP1B2 NM_001678 P14415
      Mouse Atp1b2 NM_013415 P14231
      Rat Atp1b2 NM_012507 P13638
      ATP1B3 Human ATP1B3 NM_001679 P54709
      Mouse Atp1b3 NM_007502 P97370
      Rat Atp1b3 NM_012913 Q63377
      ATP1B4 Human ATP1B4 NM_001142447 Q9UN42
      Mouse Atp1b4 NM_133690 Q99ME6
      Rat Atp1b4 NM_053381 Q9R193