Selective Na+, K+-ATPase inhibitor.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 10 mM in water and to 100 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 584.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.71 mL||8.55 mL||17.1 mL|
|5 mM||0.34 mL||1.71 mL||3.42 mL|
|10 mM||0.17 mL||0.86 mL||1.71 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References are publications that support the biological activity of the product.
Croyle et al (1997) Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 248 488 PMID: 9346307
Hosoi et al (1997) Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes. J.Neurochem. 69 2189 PMID: 9349566
Marjorie et al (1997) Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 356 203 PMID: 9272726
Merck Index 12 7031
If you know of a relevant reference for Ouabain, please let us know.
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Keywords: Ouabain, Ouabain supplier, Na+K+-ATPases, inhibitors, inhibits, Ion, Pumps, Transporters, Na+/K+, ATPase, 1076, Tocris Bioscience
4 Citations for Ouabain
Citations are publications that use Tocris products. Selected citations for Ouabain include:
Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887
Ismael-Badarneh et al (2015) The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport. PLoS One 10 e0134175 PMID: 26230832
Genda et al (2011) Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci 31 18275 PMID: 22171032
Pál et al (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Nat Neurosci 8 35 PMID: 26043770
Do you know of a great paper that uses Ouabain from Tocris? Please let us know.
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Literature in this Area
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