Ouabain

Pricing Availability   Qty
Cat.No. 1076 - Ouabain | C29H44O12 | CAS No. 630-60-4
Description: Na+/K+ ATPase inhibitor
Chemical Name: 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
Purity: ≥95% (HPLC)
Datasheet
Citations (7)
Reviews
Literature

Biological Activity

Selective Na+, K+-ATPase inhibitor.

Technical Data

M. Wt 584.66
Formula C29H44O12
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 630-60-4
PubChem ID 439501
InChI Key LPMXVESGRSUGHW-HBYQJFLCSA-N
Smiles O[C@@]12[C@@]3([H])[C@]([C@]([C@H](O)C[C@@H](O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)C4)(CO)[C@]4(O)CC3)([H])[C@H](O)C[C@@](C)1[C@@H]([C@@](CO5)=CC5=O)CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mM in water and to 100 mM in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Croyle et al (1997) Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 248 488 PMID: 9346307

Hosoi et al (1997) Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes. J.Neurochem. 69 2189 PMID: 9349566

Marjorie et al (1997) Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 356 203 PMID: 9272726

Merck Index 12 7031


If you know of a relevant reference for Ouabain, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Na+/K+ ATPase Inhibitors

Keywords: Ouabain, Ouabain supplier, Na+K+-ATPases, inhibitors, inhibits, Ion, Pumps, Transporters, Na+/K+, ATPase, 1076, Tocris Bioscience

7 Citations for Ouabain

Citations are publications that use Tocris products. Selected citations for Ouabain include:

Ismael-Badarneh et al (2015) The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport. PLoS One 10 e0134175 PMID: 26230832

Zhang et al (2019) A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells. J Biol Chem PMID: 30792309

Woo et al (2019) Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Exp Neurobiol 28 30 PMID: 30853822

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887

Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023

Pál et al (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Nat Neurosci 8 35 PMID: 26043770

Genda et al (2011) Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci 31 18275 PMID: 22171032


Do you know of a great paper that uses Ouabain from Tocris? Please let us know.

Reviews for Ouabain

There are currently no reviews for this product. Be the first to review Ouabain and earn rewards!

Have you used Ouabain?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.