Ouabain

Pricing Availability Delivery Time Qty
Cat.No. 1076 - Ouabain | C29H44O12 | CAS No. 630-60-4
Description: Na+/K+ ATPase inhibitor
Chemical Name: 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
Purity: ≥95% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Selective Na+, K+-ATPase inhibitor.

Technical Data

M. Wt 584.66
Formula C29H44O12
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 630-60-4
PubChem ID 439501
InChI Key LPMXVESGRSUGHW-HBYQJFLCSA-N
Smiles O[C@@]12[C@@]3([H])[C@]([C@]([C@H](O)C[C@@H](O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)C4)(CO)[C@]4(O)CC3)([H])[C@H](O)C[C@@](C)1[C@@H]([C@@](CO5)=CC5=O)CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.47 100
ethanol 50
water 10

Preparing Stock Solutions

The following data is based on the product molecular weight 584.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.55 mL 17.1 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
10 mM 0.17 mL 0.86 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Croyle et al (1997) Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 248 488 PMID: 9346307

Hosoi et al (1997) Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes. J.Neurochem. 69 2189 PMID: 9349566

Marjorie et al (1997) Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 356 203 PMID: 9272726

Merck Index 12 7031 PMID:


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Keywords: Na+K+-ATPases inhibitors inhibits Ion Pumps Transporters Na+/K+ ATPase

4 Citations for Ouabain

Citations are publications that use Tocris products. Selected citations for Ouabain include:

Ismael-Badarneh et al (2015) The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport. PLoS One 10 e0134175 PMID: 26230832

Pál et al (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Nat Neurosci 8 35 PMID: 26043770

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887

Genda et al (2011) Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci 31 18275 PMID: 22171032


Do you know of a great paper that uses Ouabain from Tocris? If so please let us know.

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for Ouabain

Protocols

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