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Selective Na+, K+-ATPase inhibitor.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 10 mM in water and to 100 mM in DMSO|
References are publications that support the biological activity of the product.
Croyle et al (1997) Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 248 488 PMID: 9346307
Hosoi et al (1997) Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes. J.Neurochem. 69 2189 PMID: 9349566
Marjorie et al (1997) Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 356 203 PMID: 9272726
Merck Index 12 7031
If you know of a relevant reference for Ouabain, please let us know.
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Keywords: Ouabain, Ouabain supplier, Na+K+-ATPases, inhibitors, inhibits, Ion, Pumps, Transporters, Na+/K+, ATPase, 1076, Tocris Bioscience
8 Citations for Ouabain
Citations are publications that use Tocris products. Selected citations for Ouabain include:
Zhang et al (2019) A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells. J Biol Chem PMID: 30792309
Woo et al (2019) Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Exp Neurobiol 28 30 PMID: 30853822
Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887
Romanos et al (2019) Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation. Commun Biol 2 127 PMID: 30963115
Ismael-Badarneh et al (2015) The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport. PLoS One 10 e0134175 PMID: 26230832
Genda et al (2011) Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci 31 18275 PMID: 22171032
Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023
Pál et al (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Nat Neurosci 8 35 PMID: 26043770
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