Pricing Availability   Qty
Description: Na+/K+ ATPase inhibitor
Chemical Name: 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
Purity: ≥95% (HPLC)
Citations (9)

Biological Activity for Ouabain

Ouabain is a selective Na+, K+-ATPase inhibitor. Cardiotonic agent. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.08 μM).

Technical Data for Ouabain

M. Wt 584.66
Formula C29H44O12
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 630-60-4
PubChem ID 439501
Smiles O[C@@]12[C@@]3([H])[C@]([C@]([C@H](O)C[C@H](O[C@H]4C(O)C(O)[C@@H](O)[C@H](C)O4)C5)(CO)[C@]5(O)CC3)([H])[C@H](O)C[C@]1(C)[C@@H](C(CO6)=CC6=O)CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ouabain

Solvent Max Conc. mg/mL Max Conc. mM
water 10
DMSO 58.47 100

Preparing Stock Solutions for Ouabain

The following data is based on the product molecular weight 584.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.55 mL 17.1 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
10 mM 0.17 mL 0.86 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for Ouabain

Certificate of Analysis / Product Datasheet
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References for Ouabain

References are publications that support the biological activity of the product.

Croyle et al (1997) Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 248 488 PMID: 9346307

Hosoi et al (1997) Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes. J.Neurochem. 69 2189 PMID: 9349566

Marjorie et al (1997) Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 356 203 PMID: 9272726

Merck Index 12 7031

Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed

If you know of a relevant reference for Ouabain, please let us know.

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Keywords: Ouabain, Ouabain supplier, Na+K+-ATPases, inhibitors, inhibits, Ion, Pumps, Transporters, COVID-19, MERS-CoV, middle, eastern, respiratory, virus, coronavirus, Na+/K+, ATPase, Coronavirus, 1076, Tocris Bioscience

9 Citations for Ouabain

Citations are publications that use Tocris products. Selected citations for Ouabain include:

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887

Babola et al (2020) Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. Elife 9 e52160 PMID: 31913121

Zhang et al (2019) A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells. J Biol Chem PMID: 30792309

Woo et al (2019) Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Exp Neurobiol 28 30 PMID: 30853822

Do you know of a great paper that uses Ouabain from Tocris? Please let us know.

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