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Na+/K+ ATPase modulator. Inhibits the Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Cat.No. 1076) on myogenic tone and Ca2+ signaling in rat hippocampal neurons.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 374.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.67 mL||13.35 mL||26.7 mL|
|5 mM||0.53 mL||2.67 mL||5.34 mL|
|10 mM||0.27 mL||1.34 mL||2.67 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
References are publications that support the biological activity of the product.
Ferrari (2006) Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am.J.Physiol.Regul.Integr.Comp.Physiol. 290 529 PMID: 16467500
Kirshenbaum et al (2011) Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump. Proc.Natl.Acad.Sci.U.S.A. 108 18144 PMID: 22025725
Ferrari et al (2010) Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta. 1802 1254 PMID: 20083196
Song et al (2014) Ouabain-digoxin antagonism in rat arteries and neurones. J.Physiol. 592 941 PMID: 24344167
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Keywords: Rostafuroxin, Rostafuroxin supplier, PST2238, Ouabain, inhibitors, inhibits, Na+/K+, ATPase, pump, modulators, antihypertensive, PST, 2238, 5315, Tocris Bioscience
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