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Description: Na+/K+ ATPase modulator; antihypertensive agent
Alternative Names: PST 2238
Chemical Name: 3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
Purity: ≥98% (HPLC)

Biological Activity for Rostafuroxin

Rostafuroxin is a Na+/K+ ATPase modulator. Inhibits the Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Cat.No. 1076) on myogenic tone and Ca2+ signaling in rat hippocampal neurons.

Technical Data for Rostafuroxin

M. Wt 374.51
Formula C23H34O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 156722-18-8
PubChem ID 153976
Smiles O[C@]4(C5=COC=C5)CC[C@]3(O)[C@]2([H])CC[C@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rostafuroxin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.45 100
ethanol 37.45 100

Preparing Stock Solutions for Rostafuroxin

The following data is based on the product molecular weight 374.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.35 mL 26.7 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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References for Rostafuroxin

References are publications that support the biological activity of the product.

Ferrari (2006) Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am.J.Physiol.Regul.Integr.Comp.Physiol. 290 529 PMID: 16467500

Kirshenbaum et al (2011) Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump. Proc.Natl.Acad.Sci.U.S.A. 108 18144 PMID: 22025725

Ferrari et al (2010) Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta. 1802 1254 PMID: 20083196

Song et al (2014) Ouabain-digoxin antagonism in rat arteries and neurones. J.Physiol. 592 941 PMID: 24344167

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Keywords: Rostafuroxin, Rostafuroxin supplier, PST2238, Ouabain, inhibitors, inhibits, Na+/K+, ATPase, pump, modulators, antihypertensive, PST, 2238, 5315, Tocris Bioscience

Citations for Rostafuroxin

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