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Inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.17 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 780.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.28 mL||6.4 mL||12.81 mL|
|5 mM||0.26 mL||1.28 mL||2.56 mL|
|10 mM||0.13 mL||0.64 mL||1.28 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
References are publications that support the biological activity of the product.
Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325 PMID: 15970498
Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959 PMID: 15210613
Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500 PMID: 22695717
Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed
If you know of a relevant reference for Digoxin, please let us know.
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Keywords: Digoxin, Digoxin supplier, cardiac, glycoside, digitalis, sodium, potassium, ATP, Na+, K+, ATPase, pump, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Na+/K+, Coronavirus, 4583, Tocris Bioscience
2 Citations for Digoxin
Citations are publications that use Tocris products. Selected citations for Digoxin include:
Wang et al (2017) HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia. Oncotarget 8 28074 PMID: 28427209
Wang et al (2017) HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels. Sci Rep 7 7965 PMID: 28801626
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Literature in this Area
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