Digoxin

Pricing Availability Delivery Time Qty
Cat.No. 4583 - Digoxin | C41H64O14 | CAS No. 20830-75-5
Description: Na+/K+ ATPase inhibitor
Chemical Name: 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism.

Technical Data

M. Wt 780.94
Formula C41H64O14
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 20830-75-5
PubChem ID 12940973
InChI Key LTMHDMANZUZIPE-SYUUTQQWSA-N
Smiles O=C1OC[C@]([C@H]5CC[C@]4(O)[C@]3([H])CC[C@]2([H])C[C@@H](O[C@]6([H])O[C@H](C)[C@@H](O[C@@]7([H])C[C@H](O)[C@H](O[C@]8([H])O[C@H](C)[C@@H](O)[C@@H](O)C8)[C@@H](C)O7)[C@@H](O)C6)CC[C@@](C)2[C@]([H])3C[C@@H](O)[C@]45C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 780.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.4 mL 12.81 mL
5 mM 0.26 mL 1.28 mL 2.56 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325 PMID: 15970498

Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959 PMID: 15210613

Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500 PMID: 22695717


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Keywords: cardiac glycoside digitalis sodium potassium ATP Na+ K+ ATPase pump Na+/K+ ATPase

Citations for Digoxin

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for Digoxin

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