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Biological Activity for Digoxin
Digoxin is an inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.17 μM).
Technical Data for Digoxin
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Digoxin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Digoxin
The following data is based on the product molecular weight 780.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.28 mL||6.4 mL||12.81 mL|
|5 mM||0.26 mL||1.28 mL||2.56 mL|
|10 mM||0.13 mL||0.64 mL||1.28 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
References for Digoxin
References are publications that support the biological activity of the product.
Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325 PMID: 15970498
Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959 PMID: 15210613
Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500 PMID: 22695717
Ko et al (2021) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 13 PMID: 33918958
If you know of a relevant reference for Digoxin, please let us know.
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Keywords: Digoxin, Digoxin supplier, cardiac, glycoside, digitalis, sodium, potassium, ATP, Na+, K+, ATPase, pump, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Na+/K+, Coronavirus, 4583, Tocris Bioscience
5 Citations for Digoxin
Citations are publications that use Tocris products. Selected citations for Digoxin include:
Wang et al (2017) HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia. Oncotarget 8 28074 PMID: 28427209
Wang et al (2017) HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels. Sci Rep 7 7965 PMID: 28801626
Ellen A et al (2019) Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons. J Neurosci 39 7086-7101 PMID: 31300524
Rob et al (2020) The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles. Sci Rep 10 5258 PMID: 32210283
Jing et al (2023) Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice. J Clin Invest PMID: 37227777
Do you know of a great paper that uses Digoxin from Tocris? Please let us know.
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