Digoxin

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Cat.No. 4583 - Digoxin | C41H64O14 | CAS No. 20830-75-5
Description: Na+/K+ ATPase inhibitor
Chemical Name: 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity

Inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.17 μM).

Technical Data

M. Wt 780.94
Formula C41H64O14
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 20830-75-5
PubChem ID 12940973
InChI Key LTMHDMANZUZIPE-PUGKRICDSA-N
Smiles O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@@]5(C[C@H](CC[C@@]5([C@]4(C[C@H]([C@@]32C)O)[H])C)O[C@@]6(O[C@@H]([C@H]([C@H](C6)O)O[C@]7(C[C@@H]([C@@H]([C@H](O7)C)O[C@@]8(O[C@@H]([C@H]([C@H](C8)O)O)C)[H])O)[H])C)[H])[H])=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 780.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.4 mL 12.81 mL
5 mM 0.26 mL 1.28 mL 2.56 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325 PMID: 15970498

Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959 PMID: 15210613

Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500 PMID: 22695717

Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed


If you know of a relevant reference for Digoxin, please let us know.

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Keywords: Digoxin, Digoxin supplier, cardiac, glycoside, digitalis, sodium, potassium, ATP, Na+, K+, ATPase, pump, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Na+/K+, 4583, Tocris Bioscience

2 Citations for Digoxin

Citations are publications that use Tocris products. Selected citations for Digoxin include:

Wang et al (2017) HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia. Oncotarget 8 28074 PMID: 28427209

Wang et al (2017) HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels. Sci Rep 7 7965 PMID: 28801626


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.