PACAP Receptors

Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1183 PACAP 1-27
Potent stimulator of adenylyl cyclase
1186 PACAP 1-38
Potent stimulator of adenylyl cyclase

Antagonists

Cat No Product Name / Activity
3236 PACAP 6-38
Potent PAC1 receptor antagonist

Related Targets

    Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2.

    PAC1 receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock, emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human PAC1 receptor gene has been localized to chromosome 7p14.

    External sources of pharmacological information for PACAP Receptors :

    Literature for PACAP Receptors

    GPCR

    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Secretin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
    • GPCR Signaling
    Peptide Hormone Receptors

    Peptide Hormone Receptors Product Listing

    A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

    • Anterior Pituitary Regulation
    • Blood Pressure Regulation
    • Feeding and Appetite Regulation
    • Glucose Regulation
    • Peptide Hormone Processing

    PACAP Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human ADCYAP1R1 NM_001118 P41586
    Mouse Adcyap1r1 NM_007407 P70205
    Rat Adcyap1r1 NM_133511 P32215