VIP Receptors

Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.

Products
Background
Gene Data

Agonists

Cat No Product Name / Activity
2711 Bay 55-9837
Potent and selective VPAC2 agonist
2080 PHM 27 (human)
Endogenous peptide product of human prepro-VIP
1182 VIP (guinea pig)
Involved in neurotransmission and smooth muscle relaxation
1911 VIP (human, rat, mouse, rabbit, canine, porcine)
Involved in neurotransmission and smooth muscle relaxation

Antagonists

Cat No Product Name / Activity
1172 [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)
VIP receptor antagonist
1905 VIP (6-28) (human, rat, porcine, bovine)
VIP receptor antagonist
3054 [D-p-Cl-Phe6,Leu17]-VIP
Selective VIP receptor antagonist

Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart and kidney.

VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival, regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

External sources of pharmacological information for VIP Receptors :

VIP Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
VPAC1 Human VIPR1 NM_004624 P32241
Mouse Vipr1 NM_011703 P97751
Rat Vipr1 NM_012685 P30083
VPAC2 Human VIPR2 NM_003382 P41587
Mouse Vipr2 NM_009511 P41588
Rat Vipr2 NM_017238 P35000