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PA 8 is a PAC1 receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1 or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC50 = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo.
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|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 342.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.84 mL||29.21 mL||58.42 mL|
|2.5 mM||1.17 mL||5.84 mL||11.68 mL|
|5 mM||0.58 mL||2.92 mL||5.84 mL|
|25 mM||0.12 mL||0.58 mL||1.17 mL|
References are publications that support the biological activity of the product.
Takasaki et al (2018) In silico screening identified novel small-molecule antagonists of PAC1 receptor. J.Pharmacol.Exp.Ther. 365 1 PMID: 29363578
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Keywords: PA 8, PA 8 supplier, PA8, Pituitary, adenylate, cyclase-activating, polypeptide, PACAP, receptors, antagonists, antagonism, PAC1, analgesics, analgesia, Receptors, 6657, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for PA 8 include:
Varodayan et al (2020) PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology 168 PMID: 31476352
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