PA 8

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: PAC1 receptor antagonist
Chemical Name: 2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for PA 8

PA 8 is a PAC1 receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1 or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC50 = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo.

Compound Libraries for PA 8

PA 8 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PA 8

M. Wt 342.35
Formula C17H18N4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 878437-15-1
PubChem ID 6485327
Smiles COC1=C(C=CC(C2CC(NC3=C2C(N=C(N3)N)=O)=O)=C1)OCC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PA 8

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.12 50

Preparing Stock Solutions for PA 8

The following data is based on the product molecular weight 342.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.84 mL 29.21 mL 58.42 mL
2.5 mM 1.17 mL 5.84 mL 11.68 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
25 mM 0.12 mL 0.58 mL 1.17 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for PA 8

References are publications that support the biological activity of the product.

Takasaki et al (2018) In silico screening identified novel small-molecule antagonists of PAC1 receptor. J.Pharmacol.Exp.Ther. 365 1 PMID: 29363578

If you know of a relevant reference for PA 8, please let us know.

View Related Products by Target

View Related Products by Product Action

View all PACAP Receptor Antagonists

Keywords: PA 8, PA 8 supplier, PA8, Pituitary, adenylate, cyclase-activating, polypeptide, PACAP, receptors, antagonists, antagonism, PAC1, analgesics, analgesia, Receptors, 6657, Tocris Bioscience

1 Citation for PA 8

Citations are publications that use Tocris products. Selected citations for PA 8 include:

Varodayan et al (2020) PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology 168 PMID: 31476352

Do you know of a great paper that uses PA 8 from Tocris? Please let us know.

Reviews for PA 8

There are currently no reviews for this product. Be the first to review PA 8 and earn rewards!

Have you used PA 8?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review