OX2 Receptors

The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2142 [Ala11,D-Leu15]-Orexin B
Potent, selective OX2 receptor agonist

Antagonists

Cat No Product Name / Activity
4558 EMPA
Highly potent and selective OX2 antagonist; brain penetrant
5645 IPSU
OX2 receptor antagonist; orally bioavailable
4317 JNJ 10397049
Selective OX2 receptor antagonist
3371 TCS OX2 29
Potent and selective OX2 antagonist

Related Targets

    The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B. The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).

    External sources of pharmacological information for OX2 Receptors :

    Literature for OX2 Receptors

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    OX2 Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human HCRTR2 NM_001526 O43614
    Mouse Hcrtr2 NM_198962 P58308
    Rat Hcrtr2 NM_013074 P56719