[Ala11,D-Leu15]-Orexin B

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Cat.No. 2142 - [Ala11,D-Leu15]-Orexin B | Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-D-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 | CAS No. 532932-99-3
Description: Potent, selective OX2 receptor agonist
Datasheet
Citations (4)
Literature

Biological Activity

Highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.

Technical Data

M. Wt 2857.28
Formula C120H206N44O35S
Sequence RSGPPGLQGRAQRLLQASGNHAAGILTM

(Modifications: Met-28 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 532932-99-3
PubChem ID 16201464
InChI Key SURUUKNICBOUOQ-JNZZMZGCSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.30 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2857.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.35 mL 1.75 mL 3.5 mL
5 mM 0.07 mL 0.35 mL 0.7 mL
10 mM 0.03 mL 0.17 mL 0.35 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Asahi et al (2003) Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B. Bioorg.Med.Chem.Lett. 13 111 PMID: 12467628


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Keywords: [Ala11,D-Leu15]-Orexin B, supplier, Potent, selective, OX2, receptor, agonists, Orexin2, Receptors, [Ala11D-Leu15]-OrexinB, OX2, Receptor, OX2, Receptor, Tocris Bioscience

4 Citations for [Ala11,D-Leu15]-Orexin B

Citations are publications that use Tocris products. Selected citations for [Ala11,D-Leu15]-Orexin B include:

Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004 PMID: 22652455

Shahid et al (2012) Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex. Br J Pharmacol 165 2292 PMID: 21951179

Malherbe et al (2009) Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br J Pharmacol 156 1326 PMID: 19751316

Moore et al (2014) Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse. Respir Physiol Neurobiol 200 118 PMID: 24929062


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