OX1 Receptors

The OX1 receptors, also known as hypocretin receptor 1, are located primarily in the ventromedial hypothalamus, locus coeruleus, median raphe, hippocampus and taenia tecta where they are thought to regulate sleep-wakefulness and energy homeostasis, particularly food intake.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
5115 OXA (17-33)
Potent and selective peptide OX1 agonist

Antagonists

Cat No Product Name / Activity
4983 ACT 335827
Potent and selective OX1 antagonist
1960 SB 334867
Selective non-peptide OX1 antagonist
1963 SB 408124
Selective non-peptide OX1 antagonist
4673 SB 674042
Potent and selective non-peptide OX1 antagonist

Related Targets

    The OX1 receptors, also known as hypocretin receptor 1, are located primarily in the ventromedial hypothalamus, locus coeruleus, median raphe, hippocampus and taenia tecta where they are thought to regulate sleep-wakefulness and energy homeostasis. The OX1 receptor displays higher affinity for Orexin A over Orexin B. The human OX1 receptor gene has been localized to chromosome 1 (1p33).

    External sources of pharmacological information for OX1 Receptors :

    Literature for OX1 Receptors

    GPCR

    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Secretin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
    • GPCR Signaling
    Peptide Hormone Receptors

    Peptide Hormone Receptors Product Listing

    A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

    • Anterior Pituitary Regulation
    • Blood Pressure Regulation
    • Feeding and Appetite Regulation
    • Glucose Regulation
    • Peptide Hormone Processing
    Peptides Involved in Appetite Modulation

    Peptides Involved in Appetite Modulation Scientific Review

    Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

    OX1 Receptor Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human HCRTR1 NM_001525 O43613
    Mouse Hcrtr1 NM_198959 P58307
    Rat Hcrtr1 NM_013064 P56718