YNT 185

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent and selective OX2 agonist
Chemical Name: 3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for YNT 185

YNT 185 is a potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

Compound Libraries for YNT 185

YNT 185 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YNT 185

M. Wt 688.66
Formula C33H37N5O5S.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1804978-82-2
PubChem ID 140307520
Smiles COC1=C(S(=O)(NC2=CC(NCCNC(C3=C(N(C)C)C=CC=C3)=O)=CC=C2)=O)C=C(C4=CC(C(N(C)C)=O)=CC=C4)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for YNT 185

Solvent Max Conc. mg/mL Max Conc. mM
water 68.87 100
DMSO 68.87 100

Preparing Stock Solutions for YNT 185

The following data is based on the product molecular weight 688.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.45 mL 7.26 mL 14.52 mL
5 mM 0.29 mL 1.45 mL 2.9 mL
10 mM 0.15 mL 0.73 mL 1.45 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for YNT 185

Certificate of Analysis / Product Datasheet
Select another batch:

References for YNT 185

References are publications that support the biological activity of the product.

Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 PMID: 26267383

Irukayama-Tomobe et al (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 144 5731 PMID: 28507129

If you know of a relevant reference for YNT 185, please let us know.

View Related Products by Target

View Related Products by Product Action

View all OX2 Receptor Agonists

Keywords: YNT 185, YNT 185 supplier, YNT185, orexin, receptor, 2, agonists, agonism, OX1, selective, potent, sleep, wake, cycle, nacolepsy, cataplexy, OX2, Receptor, 6739, Tocris Bioscience

Citations for YNT 185

Citations are publications that use Tocris products.

Currently there are no citations for YNT 185. Do you know of a great paper that uses YNT 185 from Tocris? Please let us know.

Reviews for YNT 185

There are currently no reviews for this product. Be the first to review YNT 185 and earn rewards!

Have you used YNT 185?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.