ACT 335827

Pricing Availability Delivery Time Qty
Cat.No. 4983 - ACT 335827 | C31H38N2O5 | CAS No. 1354039-86-3
Description: Potent and selective OX1 antagonist
Chemical Name: (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective orexin OX1 receptor antagonist (Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.

Technical Data

M. Wt 518.64
Formula C31H38N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1354039-86-3
PubChem ID 54765113
InChI Key HXHOBPVRRPCTLG-SETSBSEESA-N
Smiles O=C(NC(C)C)[C@@H]([C@]4=CC=CC=C4)N2CCC1=CC(OC)=C(OC)C=C1[C@@H]2CC3=CC(OC)=C(OC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.86 100
ethanol 51.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 518.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.64 mL 19.28 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.96 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Steiner et al (2013) Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. ChemMedChem 8 898 PMID: 23589487


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Citations for ACT 335827

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