ACT 335827

Pricing Availability   Qty
Description: Potent and selective OX1 antagonist
Chemical Name: (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for ACT 335827

ACT 335827 is a potent and selective orexin OX1 receptor antagonist (Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.

Technical Data for ACT 335827

M. Wt 518.64
Formula C31H38N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1354039-86-3
PubChem ID 54765113
Smiles O=C(NC(C)C)[C@@H]([C@]4=CC=CC=C4)N2CCC1=CC(OC)=C(OC)C=C1[C@@H]2CC3=CC(OC)=C(OC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ACT 335827

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.86 100
ethanol 51.86 100

Preparing Stock Solutions for ACT 335827

The following data is based on the product molecular weight 518.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.64 mL 19.28 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.96 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets for ACT 335827

Certificate of Analysis / Product Datasheet
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References for ACT 335827

References are publications that support the biological activity of the product.

Steiner et al (2013) Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. ChemMedChem 8 898 PMID: 23589487

If you know of a relevant reference for ACT 335827, please let us know.

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Citations for ACT 335827

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Literature in this Area

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.