OXA (17-33)

Pricing Availability   Qty
Description: Potent and selective peptide OX1 agonist
Purity: ≥95% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)

Biological Activity for OXA (17-33)

OXA (17-33) is a potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A (Cat. No. 1455).

Technical Data for OXA (17-33)

M. Wt 1749
Formula C79H125N23O22
Sequence YELLHGAGNHAAGILTL

(Modifications: Leu-33 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 343268-91-7
PubChem ID 44376806
InChI Key JPRBZUXULYLVPJ-HYNYKCRDSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OXA (17-33)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for OXA (17-33)

Certificate of Analysis / Product Datasheet
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References for OXA (17-33)

References are publications that support the biological activity of the product.

Darker et al (2001) Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor. Bioorg.Med.Chem.Lett. 11 737 PMID: 11266181

German et al (2013) Truncated orexin peptides: structure-activity relationship studies. Med.Chem.Lett. 4 1224 PMID: 24707347


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Keywords: OXA (17-33), OXA (17-33) supplier, Potent, selective, orexin, OX1, receptors, agonists, Receptor, 5115, Tocris Bioscience

3 Citations for OXA (17-33)

Citations are publications that use Tocris products. Selected citations for OXA (17-33) include:

Kelsey et al (2022) Properties and modulation of excitatory inputs to the locus coeruleus. J Physiol 600 4897-4916 PMID: 36156249

Hugh D et al (2014) Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock. J Neurosci 34 3607-21 PMID: 24599460

Feng et al (2012) Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain. Drug Des Devel Ther 12 225 PMID: 23173601


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.