OXA (17-33)

Pricing Availability   Qty
Cat.No. 5115 - OXA (17-33) | Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 | CAS No. 343268-91-7
Description: Potent and selective peptide OX1 agonist
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A (Cat. No. 1455).

Technical Data

M. Wt 1749
Formula C79H125N23O22
Sequence YELLHGAGNHAAGILTL

(Modifications: Leu-33 = C-terminal amide)

Storage Store at -20°C
CAS Number 343268-91-7
PubChem ID 44376806
InChI Key JPRBZUXULYLVPJ-HYNYKCRDSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Darker et al (2001) Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor. Bioorg.Med.Chem.Lett. 11 737 PMID: 11266181

German et al (2013) Truncated orexin peptides: structure-activity relationship studies. Med.Chem.Lett. 4 1224 PMID: 24707347


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Keywords: OXA (17-33), OXA (17-33) supplier, Potent, selective, orexin, OX1, receptors, agonists, Receptor, 5115, Tocris Bioscience

1 Citation for OXA (17-33)

Citations are publications that use Tocris products. Selected citations for OXA (17-33) include:

Feng et al (2012) Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain. Drug Des Devel Ther 12 225 PMID: 23173601


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